| Author | Griffee, Matthew J. | |
| Author | Bozza, Patrícia T. | |
| Author | Reyes, Luis Felipe | |
| Author | Eddington, Devin P. | |
| Author | Rosenberger, Dorothea | |
| Author | Merson, Laura | |
| Author | Citarella, Barbara Wanjiru | |
| Author | Fanning, Jonathon P. | |
| Author | Alexander, Peta M. A. | |
| Author | Fraser, John | |
| Author | Dalton, Heidi | |
| Author | Cho, Sung-Min | |
| Access date | 2023-11-29T01:07:22Z | |
| Available date | 2023-11-29T01:07:22Z | |
| Document date | 2023 | |
| Citation | GRIFFEE, Matthew J. et al. Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry. Research and Practice in Thrombosis and Haemostasis, v. 7, n. 5, p. 1-18, 2023. | en_US |
| ISSN | 2475-0379 | |
| URI | https://www.arca.fiocruz.br/handle/icict/61539 | |
| Description | Fernando Augusto Bozza - Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. | |
| Description | ISARIC Clinical Characterisation Group. | |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | open access | |
| Title | Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry | en_US |
| Type | Article | |
| DOI | 10.1016/j.rpth.2023.102142 | |
| Abstract | Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings. | en_US |
| Affilliation | University of Utah. Department of Anesthesiology. Salt Lake City, Utah, USA / University of Oxford. Pandemic Sciences Institute. Oxford, United Kingdom. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Immunopharmacology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Unisabana Center for Translational Science. School of Medicine. Universidad de La Sabana. Chia, Colombia. | en_US |
| Affilliation | University of Utah School of Medicine. Division of Epidemiology, Department of Internal Medicine. Salt Lake City, Utah, USA. | en_US |
| Affilliation | University of Zurich. Department of Anesthesiology. Zürich, Switzerland. | en_US |
| Affilliation | University of Oxford. Pandemic Sciences Institute. Oxford, United Kingdom. | en_US |
| Affilliation | University of Oxford. Pandemic Sciences Institute. Oxford, United Kingdom. | en_US |
| Affilliation | University of Queensland. Faculty of Medicine. Brisbane, Australia. | en_US |
| Affilliation | Department of Cardiology. Boston Children’s Hospital. Boston, Massachusetts, USA / Department of Pediatrics. Harvard Medical School. Boston, Massachusetts, USA. | en_US |
| Affilliation | University of Queensland. The Prince Charles Hospital. Critical Care Research Group. Brisbane, Australia. | en_US |
| Affilliation | Pediatric Critical Care Medicine. Heart and Vascular Institute. Inova Fairfax Hospital. Annandale, Virginia, USA. | en_US |
| Affilliation | Johns Hopkins University. Divisions of Neuroscience Critical Care and Cardiac Surgery. Departments of Neurology, Surgery, Anesthesia and Critical Care Medicine. Baltimore, Maryland, USA. | en_US |
| Subject | COVID-19 | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | Developing Countries | en_US |
| Subject | Disseminated intravascular coagulation | en_US |
| Subject | Hemorrhage | en_US |
| Subject | Ischemic stroke | en_US |
| Subject | Thromboembolism | en_US |
| Subject | Thrombosis | en_US |
| e-ISSN | 2475-0379 | |
| xmlui.metadata.dc.subject.ods | 01 Erradicação da pobreza | |
