| Author | Amorim, Ester Alves da Silva | |
| Author | França, Áquila Alcântara de | |
| Author | Pereira, Valéria Rêgo Alves | |
| Author | Brelaz-de-Castro, Maria Carolina Accioly | |
| Access date | 2023-12-13T13:22:37Z | |
| Available date | 2023-12-13T13:22:37Z | |
| Document date | 2021 | |
| Citation | AMORIM, Ester Alves da Silva et al. IL-1 family and Cutaneous Leishmaniasis: a poorly understood relationship. Cytokine & Growth Factor Reviews, v. 57, p. 85-92, Feb. 2021. | en_US |
| ISSN | 1879-0305 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/61738 | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| MeSH | Animals | en_US |
| MeSH | Cytokines | en_US |
| MeSH | Interleukin-1 | en_US |
| MeSH | Mice | en_US |
| MeSH | Leishmaniasis Cutaneous | en_US |
| MeSH | Th1 Cells | en_US |
| Title | IL-1 family and Cutaneous Leishmaniasis: A poorly understood relationship | en_US |
| Type | Article | |
| DOI | 10.1016/j.cytogfr.2020.06.007 | |
| Abstract | The cytokines of the interleukin (IL) -1 family act in the initiation of an effective immune response in Leishmania infection, represented mainly by the T helper 1 (Th1) profile, in addition to being associated with disease exacerbation and controversial contributions in the Th2 responses. The family also includes members who self-regulate inflammation, such as antagonists and anti-inflammatory cytokines, most of which have not yet been studied in Cutaneous Leishmaniasis (CL) in humans. Here we summarize findings about what is known so far about the role of these cytokines in mice, the main study model, and in humans. We reinforce the importance of studies of these cytokines as new targets in the context of CL. | en_US |
| Affilliation | Federal University of Pernambuco. Academic Center of Vitória. Vitória de Santo Antão, PE, Brazil / Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Immunology. Recife, PE, Brazil. | |
| Affilliation | Federal University of Pernambuco. Academic Center of Vitória. Vitória de Santo Antão, PE, Brazil / Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Immunology. Recife, PE, Brazil. | |
| Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Immunology. Recife, PE, Brazil. | |
| Affilliation | Federal University of Pernambuco. Academic Center of Vitória. Vitória de Santo Antão, PE, Brazil / Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Immunology. Recife, PE, Brazil. | |
| Subject | Cutaneous leishmaniasis | en_US |
| Subject | Cytokines | en_US |
| Subject | IL-1 family | en_US |
| Subject | Immune response | en_US |
| Subject | Inflammation | en_US |
| Embargo date | 2030-12-31 | |
