| Author | Castro, Nathalie De | |
| Author | Chazallon, Corine | |
| Author | Brites, Carlos | |
| Author | Messou, Eugène | |
| Author | Khosa, Celso | |
| Author | Laureillard, Didier | |
| Author | Chau, Giang D. | |
| Author | Pilotto, José H. | |
| Author | Eholié, Serge | |
| Author | Delaugerre, Constance | |
| Author | Molina, Jean-Michel | |
| Author | Wittkop, Linda | |
| Author | Grinsztejn, Beatriz | |
| Author | Marcy, Olivier | |
| Access date | 2023-12-22T22:26:08Z | |
| Available date | 2023-12-22T22:26:08Z | |
| Document date | 2023 | |
| Citation | CASTRO, Nathalie De et al. Virologic response to antiretroviral therapy in people with HIV and tuberculosis in high tuberculosis burden countries. AIDS, v. 37, n. 12, p. 1837-1842, Oct. 2023. | en_US |
| ISSN | 0269-9370 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/61937 | |
| Language | eng | en_US |
| Publisher | Gower Academic Journals | en_US |
| Rights | restricted access | |
| Title | Virologic response to antiretroviral therapy in people with HIV and tuberculosis in high tuberculosis burden countries | en_US |
| Type | Article | |
| DOI | 10.1097/QAD.0000000000003521 | |
| Abstract | Objective: We sought to compare virologic outcomes on antiretroviral therapy (ART) between people with HIV (PWH) also treated for tuberculosis in the different countries who participated to two randomized trials. Design: Pooled analysis of two randomized clinical trials. Methods: In the phase II Reflate TB and phase III Reflate TB2 trials conducted in Brazil, Côte d'Ivoire, Mozambique and Vietnam, ART-naïve PWH treated for tuberculosis were randomized to receive raltegravir or efavirenz. We assessed country differences in baseline characteristic using Wilcoxon tests and chi-square, or Fisher's exact test. We used logistic regression to analyze determinants of virologic success, defined as week-48 plasma HIV-1 RNA <50 copies/ml. Results: Of 550 participants (140 from Brazil, 170 from Côte d'Ivoire, 129 from Mozambique and 111 from Vietnam) with median baseline HIV-1 RNA of 5.4 log 10 copies/ml, 362 (65.8%) achieved virologic success at week 48. Virologic success rates were: 105/140 (75.0%) in Brazil, 99/170 (58.2%) in Côte d'Ivoire, 84/129 (65.1%) in Mozambique and 74/111 (66.7%) in Vietnam ( P = 0.0233). Baseline HIV-1 RNA, but not the country, was independently associated with virologic success: baseline HIV-1 RNA ≥500 000 copies/ml (reference), HIV RNA <100 000 copies/ml odds ratio 3.12 [95% confidence interval (CI) 1.94; 5.01] and HIV-1 RNA 100 000-499 999 copies/ml odds ratio: 1.80 (95% CI 1.19; 2.73). Overall, 177/277 (63.9%) patients treated with raltegravir and 185/273 (67.9%) patients treated with efavirenz had a plasma HIV-1 RNA <50 copies/ml at week 48. Conclusions: Virologic response to antiretroviral therapy in PWH with TB varied across countries but was mainly driven by levels of pretreatment HIV-1 RNA. | en_US |
| Affilliation | University of Bordeaux. National Institute for Health and Medical Research. Research Institute for Sustainable Development. Bordeaux Population Health Centre. Bordeaux, France / Infectious Diseases Department. AP-HP-Hôpital Saint-Louis Lariboisière. Paris, France. | en_US |
| Affilliation | University of Bordeaux. National Institute for Health and Medical Research. Research Institute for Sustainable Development. Bordeaux Population Health Centre. Bordeaux, France. | en_US |
| Affilliation | Hospital Universitário Professor Edgar Santos. Laboratório de Pesquisa em Doenças Infecciosas. Salvador, BA, Brasil. | en_US |
| Affilliation | Programme PACCI/ANRS Research Center / Centre de Prise en Charge de Recherche et de Formation. CePReF-Aconda-VS. Abidjan, Cote D'Ivoire / Département de Dermatologie et d'Infectiologie. UFR des Sciences Médicales. Université Félix Houphouët Boigny, Abidjan, Cote d'Ivoire. | en_US |
| Affilliation | Instituto Nacional de Saúde. Marracuene, Mozambique. | en_US |
| Affilliation | Department of Infectious and Tropical Diseases. Nimes University Hospital. Nimes / Research Unit 1058. Pathogenesis and Control Chronical Infections, INSERM. French Blood Center. University of Montpellier. Montpellier, France. | en_US |
| Affilliation | Pham Ngoc Thach Hospital. Ho Chi Minh City, Vietnam. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Programme PACCI/ANRS Research Center / Département de Dermatologie et d'Infectiologie. UFR des Sciences Médicales. Université Félix Houphouët Boigny, Abidjan, Cote d'Ivoire. | en_US |
| Affilliation | Virology department. APHP-Hôpital Saint-Louis / INSERM U944 / Université Paris. Cité, Paris. | en_US |
| Affilliation | Infectious Diseases Department, AP-HP-Hôpital Saint-Louis Lariboisière, Paris, France / INSERM U944 / Université Paris. Cité, Paris. | en_US |
| Affilliation | University Bordeaux, INSERM. Institut Bergonié, Bordeaux / INRIA SISTM team, Talence / CHU de Bordeaux. Service d'information médicale, INSERM. Institut Bergonié. Bordeaux, France. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | University of Bordeaux. National Institute for Health and Medical Research. Research Institute for Sustainable Development. Bordeaux Population Health Centre. Bordeaux, France. | en_US |
| Subject | HIV viral load | en_US |
| Subject | Tuberculosis | en_US |
| Subject | Virologic success | en_US |
| e-ISSN | 1473-5571 | |
| Embargo date | 2030-12-31 | |
