| Author | Alvarenga, L. | |
| Author | Cardozo, L. F. M. F. | |
| Author | Ribeiro-Alves, M. | |
| Author | Damasceno, N. R. T. | |
| Author | Berretta, A. A. | |
| Author | Lima, J. A. | |
| Author | Khosla, P. | |
| Author | Fouque, D. | |
| Author | Mafra, D. | |
| Access date | 2023-12-27T00:48:15Z | |
| Available date | 2023-12-27T00:48:15Z | |
| Document date | 2023 | |
| Citation | ALVARENGA, L. et al. Effects of turmeric extract supplementation on the lipid and lipoprotein subfraction profile in hemodialysis patients: A randomised, double-blind, crossover and controlled trial. Phytotherapy Research, v. 37, n. 8, p. 3424-3437, Aug. 2023. | en_US |
| ISSN | 0951-418X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/61997 | |
| Language | eng | en_US |
| Publisher | Heyden & Son | en_US |
| Rights | restricted access | |
| Title | Effects of turmeric extract supplementation on the lipid and lipoprotein subfraction profile in hemodialysis patients: A randomised, double-blind, crossover and controlled trial | en_US |
| Type | Article | |
| DOI | 10.1002/ptr.7814 | |
| Abstract | Dyslipidemia is common in patients with chronic kidney disease. Curcumin, a bioac tive polyphenol from Curcuma longa, can improve lipid profile. This study aims to ana lyze the effects of Curcuma Longa extract supplementation on lipid profile and lipoprotein subfractions in hemodialysis (HD) patients. This is a longitudinal, double blind, washout-period randomized clinical trial. The patients were randomized into two groups: the curcumin group (n = 10) (orange and carrot juice with 2.5 g of Cur cuma Longa extract) and the control group (n = 11) (juice without curcumin) 3x/w during HD sessions for 3 months. After the washout period, patients continued the supplementation as a crossover for the same period. The lipid profile was measured using enzymatic assays. The high-density lipoprotein and low-density lipoprotein subfractions analyses were performed using LipoprintTM. In the curcumin group, the triglyceride values tended to decrease with a different triglyceride variation between the pre and post-intervention for the control and curcumin groups of 38.5 (19.8) mg/dL (p = 0.06). There was no statistical difference in the others parameters. In conclusion, Curcuma longa extract may be a good nutritional strategy to reduce tri glyceride plasma levels in hemodialysis patients, but it seems ineffective for the other parameter. | en_US |
| Affilliation | Federal University of Rio de Janeiro. Graduate Program in Biological Sciences-Physiology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fluminense Federal University. Graduate Program in Cardiovascular Sciences. Niterói, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectology. HIV/AIDS Clinical Research Center. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | University of São Paulo. Faculty of Public Health. Department of Nutrition. São Paulo, SP, Brazil. | en_US |
| Affilliation | Apis Flora Indl. Coml. Ltda. Research, Development and Innovation Department. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Apis Flora Indl. Coml. Ltda. Research, Development and Innovation Department. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Wayne State University. Department of Nutrition and Food Science. Detroit, Michigan, USA. | en_US |
| Affilliation | Université de Lyon. Centre Hopitalier Lyon Sud. Department of Nephrology. Lyon, France. | en_US |
| Affilliation | Federal University of Rio de Janeiro. Graduate Program in Biological Sciences-Physiology. Rio de Janeiro, RJ, Brazil. | en_US |
| Subject | Chronic Kidney Diseases | en_US |
| Subject | Curcuma Longa Extract | en_US |
| Subject | Curcumin | en_US |
| Subject | Hemodialysis | en_US |
| Subject | Lipid Profile | en_US |
| Subject | Lipid Subfractions | en_US |
| e-ISSN | 1099-1573 | |
| Embargo date | 2030-12-31 | |
