| Author | Mendes-de-Almeida, Daniela P. | |
| Author | Andrade, Francianne G. | |
| Author | Carvalho, Maria do Perpétuo Socorro Sampaio | |
| Author | Córdoba, José Carlos | |
| Author | Souza, Marcelo dos Santos | |
| Author | Chagas Neto, Paulo | |
| Author | Spector, Logan G. | |
| Author | Pombo-de-Oliveira, Maria S. | |
| Access date | 2024-01-09T12:40:18Z | |
| Available date | 2024-01-09T12:40:18Z | |
| Document date | 2023 | |
| Citation | MENDES-DE-ALMEIDA, Daniela P. et al. Identifying childhood leukemia with an excess of hematological malignancies in first-degree relatives in Brazil. Frontiers in Oncology, p. 1-9, Jun. 2023. | en_US |
| ISSN | 2234-943X | |
| URI | https://www.arca.fiocruz.br/handle/icict/62118 | |
| Language | eng | en_US |
| Publisher | Frontiers Research Foundation | en_US |
| Rights | open access | en_US |
| Title | Identifying childhood leukemia with an excess of hematological malignancies in first-degree relatives in Brazil | en_US |
| Type | Article | en_US |
| DOI | 10.3389/fonc.2023.1207695 | |
| Abstract | Background: Familial aggregation in childhood leukemia is associated with epidemiological and genomic factors. Albeit epidemiological studies on the familial history of hematological malignancies (FHHMs) are scarce, genome-wide studies have identified inherited gene variants associated with leukemia risk. We revisited a dataset of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) patients to explore the familial aggregation of malignancies among their relatives. Methods: A series of 5,878 childhood leukemia (≤21 years of age) from the EMiLI study (2000-2019) were assessed. Lack of well-documented familial history of cancer (FHC) and 670 cases associated with genetic phenotypic syndromes were excluded. Leukemia subtypes were established according to World Health Organization recommendations. Logistic regression-derived odds ratios (ORs) and 95% confidence intervals (CIs) were performed and adjusted by age as a continuous variable, where ALL was the reference group for AML and conversely. The pedigree of 18 families with excess hematological malignancy was constructed. Results: FHC was identified in 472 of 3,618 eligible cases (13%). Ninety-six of the 472 patients (20.3%) had an occurrence of FHHMs among relatives. Overall, FHC was significantly associated with AML (OR, 1.36; 95% CI, 1.01-1.82; p = 0.040). Regarding the first-degree relatives, the OR, 2.92 95% CI,1.57-5.42 and the adjOR, 1.16 (1.03-1.30; p0.001) were found for FHC and FHHM, respectively. Conclusion: Our findings confirmed that AML subtypes presented a significant association with hematological malignancies in first-degree relatives. Genomic studies are needed to identify germline mutations that significantly increase the risk of developing myeloid malignancies in Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Department of Hematology. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Research Center. Rio de Janeiro, RJ, Brasil / University of Minnesota. Department of Pediatrics. Division of Epidemiology and Clinical Research. Minneapolis, MN, USA. | en_US |
| Affilliation | Instituto Nacional de Câncer. Research Center. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Hospital Foundation of Hematology and Hemotherapy of Amazonas. Department of Pediatric Hematology. Manaus, AM, Brazil. | en_US |
| Affilliation | Children's Hospital of Brasília Jose Alencar. Department of Pediatric Hematology. Brasília, DF, Brazil. | en_US |
| Affilliation | Children's Oncological and Hematological Treatment Center - Rosa Pedrossian Regional Hospital. Department of Pediatric Hematology. Campo Grande, MS, Brazil. | en_US |
| Affilliation | National Cancer Institute. Research Center. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | University of Minnesota. Department of Pediatrics. Division of Epidemiology and Clinical Research. Minneapolis, MN, USA. | en_US |
| Affilliation | National Cancer Institute. Research Center. Rio de Janeiro, RJ, Brazil. | en_US |
| Subject | Brazil | en_US |
| Subject | Childhood Leukemia | en_US |
| Subject | Familial History of Hematological Disorders | en_US |
| Subject | Lymphoblastic Acute Leukemia | en_US |
| Subject | Myeloid Leukemia | en_US |
| e-ISSN | 2234-943X | |
