Author | Alcântara, João Arthur | |
Author | Araújo, Francys Sayara Andrade de | |
Author | Paz, Andréia da Costa | |
Author | Alencar, Rodrigo Maciel | |
Author | Caldas, Berta Yoná de Albuquerque | |
Author | Monteiro, Wuelton Marcelo | |
Author | Sampaio, Vanderson de Souza | |
Author | Secundino, Nágila Francinete Costa | |
Author | Duarte, Ana Paula Marques | |
Author | Santana, Rosa Amélia Gonçalves | |
Author | Pimenta, Paulo Filemon Paolucci | |
Access date | 2024-01-17T12:45:48Z | |
Available date | 2024-01-17T12:45:48Z | |
Document date | 2023 | |
Citation | ALCÂNTARA, João Arthur et al. Effect of fluralaner on the biology, survival, and reproductive fitness of the neotropical malaria vector Anopheles aquasalis. Malaria Journal, v. 22, p. 1-10, 2023. | en_US |
ISSN | 1475-2875 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/62215 | |
Language | eng | en_US |
Publisher | BioMed Central | en_US |
Rights | open access | en_US |
Title | Effect of Fluralaner on the biology, survival, and reproductive fitness of the Neotropical malaria vector Anopheles aquasalis | en_US |
Type | Article | en_US |
DOI | 10.1186/s12936-023-04767-0 | |
Abstract | Background: Reducing mosquito abundance or interfering with its ability to support the parasite cycle can help to interrupt malaria in areas of significant risk of malaria transmission. Fluralaner is a safe and effective drug for veterinary use indicated for the treatment against fleas and ticks which acts as an antagonist of chloride ion channels mediated by γ-aminobutyric acid (GABA), preventing the entry of these ions into the postsynaptic neuron, leading to hyperexcitability of the postsynaptic neuron of the central nervous system of arthropods. Fluralaner demonstrated insecticidal activity against different insect species.
Methods: The study aimed to evaluate the effects of fluralaner on the biology, survival, and reproductive fitness of Anopheles aquasalis. The following lethal concentrations (LC) were determined for An. aquasalis: LC5 = 0.511 µM; LC25 = 1.625 µM; LC50 = 3.237 µM. Results: A significant decrease (P < 0.001) was evident in the number of eggs, larvae, and pupae in the group exposed to a sublethal dose of fluralaner when compared to a control group (without the drug). Using blood from dogs after administration of fluralaner, it was observed that the drug causes 100% mortality in An. aquasalis in less than 24 h after feeding; this effect remains even after 90 days in all samples. Discussion: Fluralaner showed the same result for up to 60 days, and after that, there was a slight reduction in its effect, evidenced by a decrease in the percentage of dead females; however, still significant when compared to the control group. Conclusion: Fluralaner affects the biology and reduction of survival in An. aquasalis in a lasting and prolonged period, and its fecundity with lower dosages, is a strong candidate for controlling disease vectors. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Departamento de Ensino e Pesquisa. Manaus, AM, Brazil / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
Subject | Malaria | |
Subject | Vector Anopheles aquasalis | |
Subject | Mosquito | |
Subject | Fluralaner | |