| Author | Pestana, Rodrigo Mendonça Cardoso | |
| Author | Carvalho, Andréa Teixeira | |
| Author | Santos, Luara Isabela dos | |
| Author | Oliveira, Angélica N. de | |
| Author | Soares, Cintia E. | |
| Author | Sabino, Adriano de P. | |
| Author | Simões, Ricardo | |
| Author | Gomes, Karina B. | |
| Access date | 2024-01-17T13:13:06Z | |
| Available date | 2024-01-17T13:13:06Z | |
| Document date | 2024 | |
| Citation | PESTANA, Rodrigo Mendonça Cardoso et al. Microparticles and cardiotoxicity secondary to doxorubicin-based chemotherapy in breast cancer patients. International Journal of Cardiology, v. 395, p. 1-8, Jan. 2024. | en_US |
| ISSN | 0167-5273 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/62218 | |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | restricted access | |
| Title | Microparticles and cardiotoxicity secondary to doxorubicin-based chemotherapy in breast cancer patients | en_US |
| Type | Article | |
| DOI | 10.1016/j.ijcard.2023.131435 | |
| Abstract | Doxorubicin (DOXO)-cardiotoxicity is a limiting factor for breast cancer chemotherapy. The relationship between microparticles (MPs) and cardiotoxicity remains unclear. MPs can be released under varying pathophysiological conditions. Thereby, this study aimed to assess MPs derived from cardiomyocytes (CardioMPs), platelets (PMPs) and those that expresses tissue factor (TFMPs) in 80 women with breast cancer undergoing DOXO-based chemotherapy, with or without cardiotoxicity in a one-year follow-up. We observed in the cardiotoxicity group higher count of total-MPs at T0 (prior chemotherapy) (p = 0.034), CardioMPs at T0 and T1 (just after chemotherapy) (p = 0.009 and p = 0.0034) and TFMPs at T0 (p = 0.011) compared to non-cardiotoxicity group. The results suggest that MPs could be associated to cardiotoxicity due to DOXO treatment in breast cancer patients. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil / Universidade Federal do Maranhão. Departamento de Ciências Fisiológicas. São Luís, MA, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Instituto de Hipertensão. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Hospitalar do Estado de Minas Gerais. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Instituto de Hipertensão. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, Brazil. | en_US |
| Subject | Breast cancer | en_US |
| Subject | Doxorubicin | en_US |
| Subject | Cardiotoxicity | en_US |
| Subject | Microparticles | en_US |
| Embargo date | 3100-12-31 | |
