Author | Souza, Alex Bruno da Silva | |
Author | Oliveira, Cíntia de Lima | |
Author | Costa, Wéslei Almeida | |
Author | Teixeira, Márcia Cristina Aquino | |
Author | Souza, Joelma Nascimento de | |
Author | Barreto, Nilo Manoel Pereira Vieira | |
Author | Oliveira, Ricardo Riccio | |
Author | Soares, Neci Matos | |
Access date | 2024-01-24T12:09:54Z | |
Available date | 2024-01-24T12:09:54Z | |
Document date | 2023 | |
Citation | SOUZA, Alex Bruno da Silva et al. Modulation of circulating cytokine production in alcoholic patients infected with Strongyloides stercoralis. Parasite Immunology, v. 45, n. 5, p. 1-6, 2023 | en_US |
ISSN | 0141-9838 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/62349 | |
Sponsorship | Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Universidade Federal da Bahia (UFBA). | en_US |
Language | eng | en_US |
Publisher | Wiley | en_US |
Rights | open access | en_US |
Subject in Portuguese | Alcoólatras | en_US |
Subject in Portuguese | Citocina | en_US |
Subject in Portuguese | Strongyloides stercoralis | en_US |
Title | Modulation of circulating cytokine production in alcoholic patients infected with Strongyloides stercoralis | en_US |
Type | Article | en_US |
DOI | 10.1111/pim.12977 | |
Abstract | Strongyloidiasis control is associated with a Th2 immune response. However, alcohol ingestion plays an important role in modulating the immune system. The aim of this study is to evaluate the occurrence of Strongyloides stercoralis infection in alcoholic patients, the levels of circulating cytokines (IFN-γ, IL-2, IL-4, IL-5, IL-10, IL-15 and IL-17), and its correlation with modulation of parasitic load in alcoholic individuals infected with S. stercoralis. A total of 336 alcoholic patients, treated at the Alcoholic Care and Treatment Center were included in this study. The cytokine levels were measured by a commercial ELISA in 80 sera divided into four groups with 20 individuals each: alcoholics infected (ASs+) and not infected (ASs-) with S. stercoralis and non-alcoholics infected (NASs+) and not infected (NASs-) with the helminth. S. stercoralis frequency in alcoholic patients was 16.1% (54/336). The parasitic load varied from 1 to 546 larvae/g of faeces, median and interquartile range (IQR) of 9 and 1.0–62.5 larvae/g of faeces, while in non-alcoholic individuals the parasitic load was less than 10 larvae/g of faeces. Levels of circulating IL-4 were significantly higher in ASs+ when compared with NASs- group (p < .05). An inverse correlation between serum levels of IFN-γ and parasitic load in alcoholic patients infected with S. stercoralis was observed (r = −601; p < 0.01). These results suggest that modulation of IFN-γ production occurs in alcoholic individuals with high parasitic burden. | en_US |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
Subject | Alcoholics | en_US |
Subject | Cytokin | en_US |
Subject | Strongyloides stercoralis | en_US |
DeCS | Alcoólatras | en_US |
DeCS | Citocinas | en_US |
DeCS | Strongyloides stercoralis | en_US |