| Author | Machado, Luiz Felipe Carreiro | |
| Author | Marinho, Juliane Zacour | |
| Author | Lima, Renata Cristina de | |
| Author | Ceravolo, Isabela Penna | |
| Author | Dias-Souza, Marcus Vinícius | |
| Access date | 2024-01-25T18:39:12Z | |
| Available date | 2024-01-25T18:39:12Z | |
| Document date | 2023 | |
| Citation | MACHADO, Luiz Felipe Carreiro et al. Rapidly synthesized zinc oxide nanoparticles can increase the activity of antimicrobial drugs against clinical isolates of Pseudomonas aeruginosa and Escherichia coli. ACTA Pharmaceutica Sciencia, v. 61, n. 4, p. 414-428, 2023 DOI : 10.23893/1307-2080.APS6127 | en_US |
| ISSN | 1307-2080 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/62381 | |
| Language | eng | en_US |
| Publisher | Behalf of the İstanbul Medipol University | en_US |
| Rights | restricted access | |
| Title | Rapidly synthesized zinc oxide nanoparticles can increase the activity of antimicrobial drugs against clinical isolates of Pseudomonas aeruginosa and Escherichia coli | en_US |
| Type | Article | |
| Abstract | This study aimed to investigate the effectiveness of combining zinc oxide nanoparticles (ZON) to antimicrobial drugs against clinical isolates of Pseudomonas aeruginosa and Escherichia coli. We explored two different methods to combine nitrofurantoin, cefepime, imipenem, azithromycin, gentamicin and sulfamethoxazole to ZON, using paper disks and 96 well plates. ZON was synthesized using the microwave-hydrothermal method and was characterized by UV-visible and Raman spectroscopy, X-ray diffraction, scanning electron microscopy and energy-dispersive X-ray spectroscopy. ZON cytotoxicity was tested against BGM cells, and its anti-inflammatory potential was also tested in vitro. The nanoparticles average size was of approximately 85 nm, and they decreased significantly the minimal inhibitory concentration of the tested antimicrobial drugs (ranging from 16 to more than 2000 times) when combined to them at the concentrations of 8 or 16 ?g/mL - except for azithromycin against E. coli isolates. It also lacked cytotoxicity even at 1000 ?g/mL. ZON were more effective than tenoxicam on the anti-inflammatory test. Further in vivo studies are necessary to set safe doses on living organisms. | en_US |
| Affilliation | Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, Brazil | en_US |
| Affilliation | Chemistry Institute. Federal University of Uberlândia. Uberlândia, MG, Brazil | en_US |
| Affilliation | Chemistry Institute. Federal University of Uberlândia. Uberlândia, MG, Brazil | en_US |
| Affilliation | René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, Brazil | en_US |
| Subject | Antimicrobial | en_US |
| Subject | cytotoxicity | en_US |
| Subject | Escherichia coli | en_US |
| Subject | Pseudomonas aeruginosa | en_US |
| Subject | zinc oxide nanoparticles | en_US |
| Embargo date | 3100-12-31 | |
