| Author | Aikawa, Nadia Emi | |
| Author | Borba, Eduardo Ferreira | |
| Author | Balbi, Verena Andrade | |
| Author | Sallum, Adriana Maluf Elias | |
| Author | Buscatti, Izabel Mantovani | |
| Author | Campos, Lucia Maria Arruda | |
| Author | Kozu, Kátia Tomie | |
| Author | Garcia, Cristiana Couto | |
| Author | Capão, Artur Silva Vidal | |
| Author | Proença, Adriana Coracini Tonacio de | |
| Author | Leon, Elaine Pires | |
| Author | Duarte, Alberto José da Silva | |
| Author | Lopes, Marta Heloisa | |
| Author | Silva, Clovis Artur | |
| Author | Bonfá, Eloisa | |
| Access date | 2024-01-25T19:22:53Z | |
| Available date | 2024-01-25T19:22:53Z | |
| Document date | 2023 | |
| Citation | AIKAWA, Nadia Emi et al. Safety and immunogenicity of influenza A(H3N2) component vaccine in juvenile systemic lupus erythematosus. Adv Rheumatol., v. 63. n. 1, 55, 2023. doi: 10.1186/s42358-023-00339-7. | en_US |
| ISSN | 2523-3106 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/62383 | |
| Language | eng | en_US |
| Publisher | BioMed Central | en_US |
| Rights | open access | en_US |
| Title | Safety and immunogenicity of influenza A(H3N2) component vaccine in juvenile systemic lupus erythematosus | en_US |
| Type | Article | en_US |
| Abstract | Introduction: Seasonal influenza A (H3N2) virus is an important cause of morbidity and mortality in the last 50 years in population that is greater than the impact of H1N1. Data assessing immunogenicity and safety of this virus component in juvenile systemic lupus erythematosus (JSLE) is lacking in the literature.
Objective: To evaluate short-term immunogenicity and safety of influenza A/Singapore (H3N2) vaccine in JSLE.
Methods: 24 consecutive JSLE patients and 29 healthy controls (HC) were vaccinated with influenza A/Singapore/INFIMH-16-0019/2016(H3N2)-like virus. Influenza A (H3N2) seroprotection (SP), seroconversion (SC), geometric mean titers (GMT), factor increase in GMT (FI-GMT) titers were assessed before and 4 weeks post-vaccination. Disease activity, therapies and adverse events (AE) were also evaluated.
Results: JSLE patients and controls were comparable in current age [14.5 (10.1-18.3) vs. 14 (9-18.4) years, p = 0.448] and female sex [21 (87.5%) vs. 19 (65.5%), p = 0.108]. Before vaccination, JSLE and HC had comparable SP rates [22 (91.7%) vs. 25 (86.2%), p = 0.678] and GMT titers [102.3 (95% CI 75.0-139.4) vs. 109.6 (95% CI 68.2-176.2), p = 0.231]. At D30, JSLE and HC had similar immune response, since no differences were observed in SP [24 (100%) vs. 28 (96.6%), p = 1.000)], SC [4 (16.7%) vs. 9 (31.0%), p = 0.338), GMT [162.3 (132.9-198.3) vs. 208.1 (150.5-287.8), p = 0.143] and factor increase in GMT [1.6 (1.2-2.1) vs. 1.9 (1.4-2.5), p = 0.574]. SLEDAI-2K scores [2 (0-17) vs. 2 (0-17), p = 0.765] and therapies remained stable throughout the study. Further analysis of possible factors influencing vaccine immune response among JSLE patients demonstrated similar GMT between patients with SLEDAI < 4 compared to SLEDAI ≥ 4 (p = 0.713), as well as between patients with and without current use of prednisone (p = 0.420), azathioprine (p = 1.0), mycophenolate mofetil (p = 0.185), and methotrexate (p = 0.095). No serious AE were reported in both groups and most of them were asymptomatic (58.3% vs. 44.8%, p = 0.958). Local and systemic AE were alike in both groups (p > 0.05). | en_US |
| Affilliation | Pediatric Rheumatology Unit. Instituto da Criança e do Adolescente. Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil/Rheumatology Division. Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Affilliation | Rheumatology Division. Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Affilliation | Pediatric Rheumatology Unit. Instituto da Criança e do Adolescente Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Affilliation | Pediatric Rheumatology Unit. Instituto da Criança e do Adolescente Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Affilliation | Pediatric Rheumatology Unit. Instituto da Criança e do Adolescente Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Affilliation | Pediatric Rheumatology Unit. Instituto da Criança e do Adolescente Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Affilliation | Pediatric Rheumatology Unit. Instituto da Criança e do Adolescente Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Affilliation | Laboratory of Respiratory, Exanthematic Viruses, Enterovirus and Viral Emergencies, Instituto Oswaldo Institute. Oswaldo Cruz Foundation. Rio de Janeiro, RJ, Brazil/Integrated Research Group On Biomarkers. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Laboratory of Respiratory, Exanthematic Viruses, Enterovirus and Viral Emergencies, Instituto Oswaldo Institute. Oswaldo Cruz Foundation. Rio de Janeiro, RJ, Brazil | en_US |
| Affilliation | Department of Infectious and Parasitic Diseases. Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Affilliation | Rheumatology Division. Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil | en_US |
| Affilliation | Clinical Laboratory Division. Department of Pathology. Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Affilliation | Department of Infectious and Parasitic Diseases. Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Affilliation | Rheumatology Division. Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil/Pediatric Rheumatology Unit. Instituto da Criança e do Adolescente Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Affilliation | Rheumatology Division. Hospital das Clinicas. Faculdade de Medicina. Universidade de Sao Paulo. Sao Paulo, SP, Brazil. | en_US |
| Subject | H3N2 | en_US |
| Subject | Immunogenicity | en_US |
| Subject | Influenza | en_US |
| Subject | Safety | en_US |
| Subject | Systemic lupus erythematosus | en_US |
| Subject | Vaccine | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
