Author | Amaral, Eduardo P. | |
Author | Namasivayam, Sivaranjani | |
Author | Queiroz, Artur T. L. | |
Author | Fukutani, Eduardo | |
Author | Hilligan, Kerry L. | |
Author | Aberman, Kate | |
Author | Fisher, Logan | |
Author | Bomfim, Caio Cesar B. | |
Author | Kauffman, Keith | |
Author | Buchanan, Jay | |
Author | Santuo, Leslie | |
Author | Guimaraes, Pedro Henrique Gazzinelli | |
Author | Costa, Diego L. | |
Author | Teixeira, Mariane Araújo | |
Author | Duarte, Beatriz Barreto | |
Author | Rocha, Clarissa Gurgel | |
Author | Santana, Monique Freire | |
Author | Santos, Marcelo Cordeiro | |
Author | Barber, Daniel L. | |
Author | Wilkinson, Robert J. | |
Author | Kramnik, Igor | |
Author | Igarashi, Kazuhiko | |
Author | Scriba, Thomas | |
Author | Barber, Katrin D. Mayer | |
Author | Andrade, Bruno B. | |
Author | Sher, Alan | |
Access date | 2024-01-31T19:32:48Z | |
Available date | 2024-01-31T19:32:48Z | |
Document date | 2024 | |
Citation | AMARAL, Eduardo P. et al. BACH1 promotes tissue necrosis and mycobacterium tuberculosis susceptibility. Nature Microbiology, v. 9, n. 1, p. 1-33, 2024. | en_US |
ISSN | 2058-5276 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/62496 | |
Sponsorship | Wellcome Trust.
Cancer Research UK.
Programa de Pesquisa Intramural da Fundação Oswaldo Cruz.
Programa de Pesquisa Intramural Fundação José Silveira.
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Programa de Pesquisa Intramural do NIAID/NIH. | en_US |
Language | eng | en_US |
Publisher | Nature Research | en_US |
Rights | open access | en_US |
Subject in Portuguese | BACH1 | en_US |
Subject in Portuguese | Necrose tecidual | en_US |
Subject in Portuguese | Micobactéria | en_US |
Subject in Portuguese | Tuberculose | en_US |
Title | BACH1 promotes tissue necrosis and mycobacterium tuberculosis susceptibility | en_US |
Type | Article | en_US |
DOI | 10.1038/s41564-023-01523-7 | |
Abstract | Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) pathogenesis. We investigated whether Bach1, a transcription factor that represses multiple antioxidant genes, regulates host resistance to Mtb. We found that BACH1 expression is associated clinically with active pulmonary tuberculosis. Bach1 deletion in Mtb-infected mice increased glutathione levels and Gpx4 expression that inhibit lipid peroxidation. Bach1-/- macrophages exhibited increased resistance to Mtb-induced cell death, while Mtb-infected Bach1-deficient mice displayed reduced bacterial loads, pulmonary necrosis and lipid peroxidation concurrent with increased survival. Single-cell RNA-seq analysis of lungs from Mtb-infected Bach1-/- mice revealed an enrichment of genes associated with ferroptosis suppression. Bach1 depletion in Mtb-infected B6.Sst1S mice that display human-like necrotic lung pathology also markedly reduced necrosis and increased host resistance. These findings identify Bach1 as a key regulator of cellular and tissue necrosis and host resistance in Mtb infection. | en_US |
Affilliation | Immunobiology Section. Laboratory of Parasitic Diseases. NIAID. NIH. Bethesda, MD, USA. | en_US |
Affilliation | Immunobiology Section. Laboratory of Parasitic Diseases. NIAID. NIH. Bethesda, MD, USA. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil. | en_US |
Affilliation | Immunobiology Section. Laboratory of Parasitic Diseases. NIAID. NIH. Bethesda, MD, USA. | en_US |
Affilliation | Immunobiology Section. Laboratory of Parasitic Diseases. NIAID. NIH. Bethesda, MD, USA. | en_US |
Affilliation | Immunobiology Section. Laboratory of Parasitic Diseases. NIAID. NIH. Bethesda, MD, USA / Immunology and Microbial Pathogenesis Program. Weill Cornell Medicine Graduate School of Medical Sciences. New York, NY, USA. | en_US |
Affilliation | Immunobiology Section. Laboratory of Parasitic Diseases. NIAID. NIH. Bethesda, MD, USA. | en_US |
Affilliation | T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institutes of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA. | en_US |
Affilliation | T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institutes of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA. | en_US |
Affilliation | T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institutes of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA. | en_US |
Affilliation | Helminth Immunology Section. Laboratory of Parasitic Diseases. National Institutes of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA. | en_US |
Affilliation | Immunobiology Section. Laboratory of Parasitic Diseases. NIAID. NIH. Bethesda, MD, USA / Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil / Universidade de São Paulo, Ribeirão Preto. Faculdade de Medicina de Ribeirão Preto. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Ribeirão Preto, SP, Brasil. | en_US |
Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Escola de Medicina. Departamento de Patologia. Salvador, BA, Brasil / Instituto D'Or de Pesquisa e Ensino. Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Centro de Controle de Oncologia do Estado do Amazonas. Departamento de Ensino e Pesquisa, Manaus, AM, Brasil / Fundação Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. | en_US |
Affilliation | Fundação Medicina Tropical Doutor Heitor Vieira Dourado. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Universidade Nilton Lins. Faculdade de Medicina. Manaus, AM, Brasil. | en_US |
Affilliation | T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institutes of Allergy and Infectious Disease. National Institutes of Health. Bethesda, MD, USA. | en_US |
Affilliation | Wellcome Centre for Infectious Disease Research in Africa. Institute of Infectious Disease and Molecular Medicine. University of Cape Town. Cape Town, South Africa / The Francis Crick Institute. London, UK / Department of Infectious Disease. Imperial College London. London, UK. | en_US |
Affilliation | Boston University School of Medicine. Boston, MA, USA. | en_US |
Affilliation | Tohoku University Graduate School of Medicine. Department of Biochemistry, Sendai, Japan. | en_US |
Affilliation | South African Tuberculosis Vaccine Initiative. Institute of Infectious Disease and Molecular Medicine and Division of Immunology. Department of Pathology. University of Cape Town. Observatory, South Africa. | en_US |
Affilliation | Inflammation and Innate Immunity Unit. Laboratory of Clinical Immunology and Microbiology. NIAID. NIH. Bethesda, MD, USA. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina. Departamento de Patologia. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine. Nashville, TN, USA. | en_US |
Affilliation | Immunobiology Section. Laboratory of Parasitic Diseases. NIAID. NIH. Bethesda, MD, USA. | en_US |
Subject | BACH1 | en_US |
Subject | Tissue necrosis | en_US |
Subject | Mycobacterium | en_US |
Subject | Tuberculosis | en_US |
DeCS | Necrose | en_US |
DeCS | Tuberculose | en_US |