| Author | Santos, Debora Regina Lopes dos | |
| Author | Carvalho, Ricardo Durães de | |
| Author | Gardinali, Noemi Rovaris | |
| Author | Machado, Lais Ceschini | |
| Author | Paula, Vanessa Salete de | |
| Author | Wallau, Gabriel da Luz | |
| Author | Oliveira, Jaqueline Mendes de | |
| Author | Pena, Lindomar José | |
| Author | Pinto, Marcelo Alves | |
| Author | Gil, Laura Helena Vega Gonzales | |
| Author | Oliveira Filho, Edmilson Ferreira de | |
| Access date | 2024-02-07T16:39:48Z | |
| Available date | 2024-02-07T16:39:48Z | |
| Document date | 2023 | |
| Citation | SANTOS, Debora Regina Lopes dos et al. Uncovering neglected subtypes and zoonotic transmission of Hepatitis E virus (HEV) in Brazil. Virology Journal, v. 20, n. 83, p. 1-7, 2 May 2023. | en_US |
| ISSN | 1743-422X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/62594 | |
| Sponsorship | Edmilson Ferreira de Oliveira Filho was supported by FACEPE (grant 1380 − 5.05/15) and CNPq (grant DCR- 0003-5.05/16) until 2018. | |
| Sponsorship | Ricardo Durães de Carvalho is supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Brazil, grants 2019/01255-9 and 2021/03684-4 (Young Investigator Program). | |
| Sponsorship | The authors also thank the National Laboratory for Scientific Computing (LNCC/MCTI, Brazil) for providing HPC resources of the Santos Dumont supercomputer (ID #45691, project “virusevolution”). | |
| Sponsorship | Open Access funding enabled and organized by Projekt DEAL. | |
| Language | eng | en_US |
| Publisher | BMC | en_US |
| Rights | open access | |
| Title | Uncovering neglected subtypes and zoonotic transmission of Hepatitis E virus (HEV) in Brazil | en_US |
| Type | Article | |
| DOI | 10.1186/s12985-023-02047-6 | |
| Abstract | Hepatitis E virus (HEV) circulation in humans and swine has been extensively studied in South America over the last two decades. Nevertheless, only 2.1% of reported HEV strains are available as complete genome sequences. Therefore, many clinical, epidemiological, and evolutionary aspects of circulating HEV in the continent still need to be clarified. Here, we conducted a retrospective evolutionary analysis of one human case and six swine HEV strains previously reported in northeastern, southern, and southeastern Brazil. We obtained two complete and four nearly complete genomic sequences. Evolutionary analysis comparing the whole genomic and capsid gene sequences revealed high genetic variability. This included the circulation of at least one unrecognized unique South American subtype. Our results corroborate that sequencing the whole capsid gene could be used as an alternative for HEV subtype assignment in the absence of complete genomic sequences. Moreover, our results substantiate the evidence for zoonotic transmission by comparing a larger genomic fragment recovered from the sample of the autochthonous human hepatitis E case. Further studies should continuously investigate HEV genetic diversity and zoonotic transmission of HEV in South America. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil / Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Departamento de Desenvolvimento Tecnológico. Laboratório de Tecnologia Virológica. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia e Parasitologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil / National Reference Center for Tropical Infectious Diseases. WHO Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research. Bernhard Nocht Institute for Tropical Medicine. Department of Arbovirology. Hamburg, Germany. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Virologia e Terapia Experimental. Recife, PE, Brasil / Humboldt-Universität zu Berlin. Corporate Member of Freie Universität Berlin. Charité-Universitätsmedizin Berlin. Institute of Virology. Berlin, Germany. | en_US |
| Subject | Hepatitis E | en_US |
| Subject | HEV | en_US |
| Subject | Zoonotic transmission | en_US |
| Subject | Genetic divergence | en_US |
| Subject | Subtypes assignment | en_US |
| e-ISSN | 1743-422X | |
