| Author | Santos, Agna F. | |
| Author | Azevedo, Maria I. | |
| Author | Amaral, Camila I. | |
| Author | Grom, Nikollye A. | |
| Author | Marinho, Fabricio | |
| Author | Oliveira, Camila S. F. de | |
| Author | Soares, Danielle F. de M. | |
| Author | Morais, Maria H. F. | |
| Author | Brandão, Silvana T. | |
| Author | Menezes, Rodrigo C. | |
| Author | Ecco, Roselene | |
| Access date | 2024-02-20T23:37:00Z | |
| Available date | 2024-02-20T23:37:00Z | |
| Document date | 2024 | |
| Citation | SANTOS, Agna F. et al. Feline sporotrichosis: Characterization of cutaneous and extracutaneous lesions using different diagnostic methods. Veterinary Pathology, v. 61, n. 2, p. 221–231, Mar. 2024. | en_US |
| ISSN | 0300-9858 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/62706 | |
| Sponsorship | The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil (CAPES- Coordination of Improvement of Higher Education Personnel), Finance Code 001, and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq-National Council for Scientific and Technological Development), Brazil. | |
| Language | eng | en_US |
| Publisher | Sage | en_US |
| Rights | restricted access | |
| Title | Feline sporotrichosis: Characterization of cutaneous and extracutaneous lesions using different diagnostic methods | en_US |
| Type | Article | |
| DOI | 10.1177/03009858231189448 | |
| Abstract | Sporotrichosis is a mycotic infection of the cutaneous and subcutaneous tissues caused by Sporothrix spp. that can also cause extracutaneous manifestations. This study aimed to characterize cutaneous and extracutaneous sporotrichosis lesions in cats. Over 1 year, 102 cats rescued by the Zoonoses Control Center of Belo Horizonte, Brazil, euthanized with clinical suspicion of feline sporotrichosis were evaluated. After euthanasia, the animals were evaluated by macroscopic, cytological, histopathological, and immunohistochemistry (IHC) examinations; fungal culture; and polymerase chain reaction (PCR). Sporothrix infection was identified by at least one diagnostic technique in all cats (n = 102) evaluated by postmortem examination, including 26/28 cases (93%) evaluated by IHC, 66/90 cases (73%) evaluated by cytology, 70/102 cases (68.6%) evaluated by histopathology, and 62/74 cases (84%) evaluated by fungal culture. Two cats had positive results only by fungal culture. Cytology and histopathology examinations were effective in diagnosing sporotrichosis, although IHC was needed to confirm the diagnosis in cats with low fungal loads. Sporothrix brasiliensis was confirmed by the sequencing of 3 samples. Skin lesions were characterized mainly by pyogranulomatous to granulomatous dermatitis (frequently with subcutaneous inflammation) with different intensities of Sporothrix spp. yeast. Extracutaneous findings associated with sporotrichosis included rhinitis or rhinosinusitis, lymphadenitis, pneumonia, meningitis, periorchitis, conjunctivitis, and glossitis. Extracutaneous infections were observed in 74/102 cases, and a possible association between the chronicity of the disease and the higher pathogenicity of this fungal species in cats requires further investigation. | en_US |
| Affilliation | Federal University of Minas Gerais. Department of Clinic and Surgery. Veterinary School. Pathology Sector and MULTILAB. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Federal University of Minas Gerais. Veterinary School. Department of Preventive Veterinary Medicine. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Federal University of Minas Gerais. Department of Clinic and Surgery. Veterinary School. Pathology Sector and MULTILAB. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Federal University of Minas Gerais. Department of Clinic and Surgery. Veterinary School. Pathology Sector and MULTILAB. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Federal University of Minas Gerais. Department of Clinic and Surgery. Veterinary School. Pathology Sector and MULTILAB. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Federal University of Minas Gerais. Veterinary School. Department of Preventive Veterinary Medicine. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Federal University of Minas Gerais. Veterinary School. Department of Preventive Veterinary Medicine. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Prefeitura Municipal de Belo Horizonte. Secretaria Municipal da Saúde. Diretoria de Zoonoses. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Prefeitura Municipal de Belo Horizonte. Secretaria Municipal da Saúde. Diretoria de Zoonoses. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Federal University of Minas Gerais. Department of Clinic and Surgery. Veterinary School. Pathology Sector and MULTILAB. Belo Horizonte, MG, Brazil. | en_US |
| Subject | Cat | en_US |
| Subject | Conjunctivitis | en_US |
| Subject | Glossitis | en_US |
| Subject | Immunohistochemistry | en_US |
| Subject | Lymphadenitis | en_US |
| Subject | Meningitis | en_US |
| Subject | Pneumonia | en_US |
| Subject | Rhinitis | en_US |
| Subject | Sporotrichosis | en_US |
| Subject | Sporothrix spp | en_US |
| e-ISSN | 1544-2217 | |
| Embargo date | 2030-12-31 | |
