| Author | Padane, Abdou | |
| Author | Tegally, Houriiyah | |
| Author | Ramphal, Yajna | |
| Author | Seyni, Ndiaye | |
| Author | Sarr, Mariéma | |
| Author | Diop, Mame Matar | |
| Author | Diedhiou, Cyrille Kouligueul | |
| Author | Mboup, Aminata | |
| Author | Diouf, Ndèye Dieyna | |
| Author | Souaré, Abdoulaye | |
| Author | Diagne, Ndéye Diabou | |
| Author | Aza-Gnandji, Marilyne | |
| Author | Dabo, Ndèye Astou | |
| Author | Dia, Yacine Amet | |
| Author | Diaw, Ndeye Aminata | |
| Author | Leye, Nafissatou | |
| Author | Diaw, Papa Alassane | |
| Author | Ahouidi, Ambroise | |
| Author | Cissé, Badara | |
| Author | Diallo, Abdoulaye Samba | |
| Author | Diop, Ousmane | |
| Author | Diallo, Abdou Aziz | |
| Author | Ndoye, Souadou | |
| Author | Sanko, Tomasz J. | |
| Author | Baxter, Cheryl | |
| Author | Wilkinson, Eduan | |
| Author | San, James E. | |
| Author | Tshabuila, Derek | |
| Author | Naidoo, Yeshnee | |
| Author | Pillay, Sureshnee | |
| Author | Lessells, Richard | |
| Author | Cissé, Khady | |
| Author | Leye, Abdoulaye | |
| Author | Mbaye, Khalifa Ababacar | |
| Author | Kania, Dramane | |
| Author | Tinto, Bachirou | |
| Author | Traoré, Isidore | |
| Author | Kagone, Sampawendé Thérèse | |
| Author | Ouedraogo, Abdoul Salam | |
| Author | Gifford, Robert J. | |
| Author | Lourenço, José | |
| Author | Giovanetti, Marta | |
| Author | Giandhari, Jennifer | |
| Author | Oliveira, Tulio de | |
| Author | Mboup, Souleymane | |
| Access date | 2024-02-22T18:14:39Z | |
| Available date | 2024-02-22T18:14:39Z | |
| Document date | 2023 | |
| Citation | PADANE, Abdou et al. An emerging clade of Chikungunya West African genotype discovered in real-time during 2023 outbreak in Senegal. medRxiv. Preprint. 2023. doi: 10.1101/2023.11.14.23298527 | |
| URI | https://www.arca.fiocruz.br/handle/icict/62750 | |
| Language | eng | en_US |
| Publisher | Cold Spring Harbor Laboratory | |
| Rights | restricted access | |
| Title | An emerging clade of Chikungunya West African genotype discovered in real-time during 2023 outbreak in Senegal | en_US |
| Type | Preprint | |
| Abstract | Chikungunya (CHIKV) is a re-emerging endemic arbovirus in West Africa. Since July 2023, Senegal and Burkina Faso have been experiencing an ongoing outbreak, with over 300 confirmed cases detected so far in the regions of Kédougou and Tambacounda in Senegal, the largest recorded outbreak yet. CHIKV is typically maintained in a sylvatic cycle in Senegal but its evolution and factors contributing to re-emergence are so far unknown in West Africa, leaving a gap in understanding and responding to recurrent epidemics. We produced, in real-time, the first locally-generated and publicly available CHIKV whole genomes in West Africa, to characterize the genetic diversity of circulating strains, along with phylodynamic analysis to estimate time of emergence and population growth dynamics. A novel strain of the West African genotype, phylogenetically distinct from strains circulating in previous outbreaks, was identified. This suggests a likely new spillover from sylvatic cycles in rural Senegal and potential of seeding larger epidemics in urban settings in Senegal and elsewhere. | en_US |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal/Centre for Epidemic Response and Innovation. School of Data Science and Computational Thinking. Stellenbosch University. Stellenbosch, South Africa. | |
| Affilliation | Centre for Epidemic Response and Innovation. School of Data Science and Computational Thinking. Stellenbosch University. Stellenbosch, South Africa. | |
| Affilliation | Centre for Epidemic Response and Innovation. School of Data Science and Computational Thinking. Stellenbosch University. Stellenbosch, South Africa. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Affilliation | Centre for Epidemic Response and Innovation. School of Data Science and Computational Thinking. Stellenbosch University. Stellenbosch, South Africa. | |
| Affilliation | Centre for Epidemic Response and Innovation. School of Data Science and Computational Thinking. Stellenbosch University. Stellenbosch, South Africa. | |
| Affilliation | Centre for Epidemic Response and Innovation. School of Data Science and Computational Thinking. Stellenbosch University. Stellenbosch, South Africa. | |
| Affilliation | Centre for Epidemic Response and Innovation. School of Data Science and Computational Thinking. Stellenbosch University. Stellenbosch, South Africa. | |
| Affilliation | Centre for Epidemic Response and Innovation. School of Data Science and Computational Thinking. Stellenbosch University. Stellenbosch, South Africa. | |
| Affilliation | Centre for Epidemic Response and Innovation. School of Data Science and Computational Thinking. Stellenbosch University. Stellenbosch, South Africa | |
| Affilliation | KwaZulu-Natal Research Innovation and Sequencing Platform. Nelson R Mandela School of Medicine. University of KwaZulu-Natal. Durban, South Africa. | |
| Affilliation | KwaZulu-Natal Research Innovation and Sequencing Platform. Nelson R Mandela School of Medicine. University of KwaZulu-Natal. Durban, South Africa. | |
| Affilliation | District of Kédougou. Kédougou, Senegal. | |
| Affilliation | District of Kédougou. Kédougou, Senegal. | |
| Affilliation | District of Kédougou. Kédougou, Senegal. | |
| Affilliation | Centre MURAZ. Bobo-Dioulasso, Burkina Faso. | |
| Affilliation | Centre MURAZ. Bobo-Dioulasso, Burkina Faso. | |
| Affilliation | Centre MURAZ. Bobo-Dioulasso, Burkina Faso. | |
| Affilliation | Centre MURAZ. Bobo-Dioulasso, Burkina Faso. | |
| Affilliation | Centre MURAZ. Bobo-Dioulasso, Burkina Faso. | |
| Affilliation | Centre for Epidemic Response and Innovation. School of Data Science and Computational Thinking. Stellenbosch University. Stellenbosch, South Africa. | |
| Affilliation | Universidade Católica Portuguesa. Faculty of Medicine, Biomedical Research Centre. Lisbon, Portugal | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | |
| Affilliation | KwaZulu-Natal Research Innovation and Sequencing Platform. Nelson R Mandela School of Medicine. University of KwaZulu-Natal. Durban, South Africa. | |
| Affilliation | Centre for Epidemic Response and Innovation. School of Data Science and Computational Thinking. Stellenbosch University. Stellenbosch, South Africa/KwaZulu-Natal Research Innovation and Sequencing Platform. Nelson R Mandela School of Medicine. University of KwaZulu-Natal. Durban, South Africa. | |
| Affilliation | Institut de Recherche en Santé, de Surveillance Épidémiologique et de Formation. Dakar, Senegal. | |
| Subject | Chikungunya virus | en_US |
| Subject | West African genotype | en_US |
| Subject | Genomic monitoring | en_US |
| Subject | Senegal | en_US |
| Subject | West Africa | en_US |
| Subject | Climate change | en_US |
| Embargo date | 2030-12-31 | |
| xmlui.metadata.dc.subject.ods | 13 Ação contra a mudança global do clima | |
