Author | Silveira, Marcelo Augusto Duarte | |
Author | Menezes, Matheus de Alencar | |
Author | Souza, Sergio Pinto de | |
Author | Galvão, Erica Batista dos Santos | |
Author | Berretta, Andresa Aparecida | |
Author | Caldas, Juliana | |
Author | Teixeira, Maurício Brito | |
Author | Gomes, Marcel Miranda Dantas | |
Author | Damiani, Lucas Petri | |
Author | Bahiense, Bruno Andrade | |
Author | Cabral, Julia Barros | |
Author | Oliveira, Cicero Wandson Luiz Macedo de | |
Author | Mascarenhas, Talita Rocha | |
Author | Pinheiro, Priscila Carvalho Guedes | |
Author | Alves, Milena Souza | |
Author | Melo, Rodrigo Morel Vieira de | |
Author | Leite, Flávia Mendes | |
Author | Nonaka, Carolina Kymie Vasques | |
Author | Souza, Bruno Solano de Freitas | |
Author | Baptista, Nathália Ursoli | |
Author | Teles, Flávio | |
Author | Guarda, Suzete Farias da | |
Author | Mendes, Ana Verena Almeida | |
Author | Passos, Rogério da Hora | |
Access date | 2024-02-23T19:25:08Z | |
Available date | 2024-02-23T19:25:08Z | |
Document date | 2023 | |
Citation | SILVEIRA, Marcelo Augusto Duarte et al. Standardized Brazilian green propolis extract (EPP‑AF®) in COVID‑19 outcomes: a randomized double‑blind placebo‑controlled trial. Scientific Reports, v. 13, n. 1, p. 1-10, 2023. | en_US |
ISSN | 2045-2322 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/62792 | |
Sponsorship | Fundação Maria Emília Pedreira Freire de Carvalho.
Instituto D’Or de Pesquisa e Ensino (IDOR).
Hospital São Rafael. | en_US |
Language | eng | en_US |
Publisher | Nature Research | en_US |
Rights | open access | en_US |
Subject in Portuguese | Epidemiologia | en_US |
Subject in Portuguese | COVID 19 | en_US |
Subject in Portuguese | Coinfecção | en_US |
Subject in Portuguese | Tratamento farmacológico | en_US |
Subject in Portuguese | Método duplo-cego | en_US |
Subject in Portuguese | Própolis | en_US |
Subject in Portuguese | Uso terapêutico | en_US |
Title | Standardized Brazilian green propolis extract (EPP‑AF®) in COVID‑19 outcomes: a randomized double‑blind placebo‑controlled trial | en_US |
Type | Article | en_US |
DOI | 10.1038/s41598-023-43764-w | |
Abstract | SARS-CoV-2 and its different variants caused a "wave and wave" pandemic pattern. During the first wave we demonstrated that standardized Brazilian green propolis extract (EPP-AF®) reduces length of hospital stay in adult patients with COVID-19. Afterwards, we decided to evaluate the impact of EPP-AF in hospitalized patients during the third wave of the pandemic. BeeCovid2 was a randomized, double-blind, placebo-controlled clinical trial in hospitalized COVID-19 adult patients. Patients were allocated to receive an oral dose of 900 mg/day of EPP-AF® or placebo for 10 days. The primary outcome was length of hospital stay. Secondary outcomes included safety, secondary infection rate, duration of oxygen therapy dependency, acute kidney injury and need for intensive care. Patients were followed up for 28 days after admission. We enrolled 188 patients; 98 were assigned to the propolis group and 90 to the placebo group. The post-intervention length of hospital stay was of 6.5 ± 6.0 days in the propolis group versus 7.7 ± 7.1 days in the control group (95% CI - 0.74 [- 1.94 to 0.42]; p = 0.22). Propolis did not have significant impact on the need for oxygen supplementation or frequency of AKI. There was a significant difference in the incidence of secondary infection between groups, with 6.1% in the propolis group versus 18.9% in the control group (95% CI - 0.28 [0.1-0.76], p = 0.01). The use of EPP-AF was considered safe and associated with a decrease in secondary infections. The drug was not associated with a significant reduction in length of hospital stay. ClinicalTrials.gov (NCT04800224). | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Apis Flora Industrial e Comercial Ltda. Departamento de Desenvolvimento e Inovação. Ribeirão Preto, SP, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital Israelita Albert Einstein. Organização de Pesquisa Acadêmica. São Paulo, SP, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina. Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Apis Flora Industrial e Comercial Ltda. Departamento de Desenvolvimento e Inovação. Ribeirão Preto, SP, Brasil. | en_US |
Affilliation | Universidade Federal de Alagoas. Escola de Medicina. Maceió, AL, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina. Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Affilliation | Hospital São Rafael. Instituto D'Or de Pesquisa e Educação (IDOR). Salvador, BA, Brasil. | en_US |
Subject | Epidemiology | en_US |
Subject | COVID-19 | en_US |
Subject | Coinfection | en_US |
Subject | Drug Therapy | en_US |
Subject | Double-blind method | en_US |
Subject | Propolis | en_US |
Subject | Therapeutic use | en_US |
DeCS | Epidemiologia | en_US |
DeCS | COVID 19 | en_US |
DeCS | Coinfecção | en_US |
DeCS | Tratamento farmacológico | en_US |
DeCS | Método duplo-cego | en_US |
DeCS | Própole | en_US |
DeCS | Uso terapêutico | en_US |