Author | Costa, Maria da Conceição N. | |
Author | Cardim, Luciana Lobato | |
Author | Moore, Cynthia A. | |
Author | Jesus, Eliene dos Santos de | |
Author | Sauer, Rita Carvalho | |
Author | Barreto, Mauricio L. | |
Author | Rodrigues, Laura C. | |
Author | Smeeth, Liam | |
Author | Faccini, Lavínia Schuler | |
Author | Brickley, Elizabeth B. | |
Author | Oliveira, Wanderson K. | |
Author | Carmo, Eduardo Hage | |
Author | Pescarini, Julia Moreira | |
Author | Andrade, Roberto F. S. | |
Author | Rodrigues, Moreno M. S. | |
Author | Veiga, Rafael V. | |
Author | Costa, Larissa C. | |
Author | França, Giovanny V. A. | |
Author | Teixeira, Maria Gloria | |
Author | Paixão, Enny S. | |
Access date | 2024-03-26T14:31:44Z | |
Available date | 2024-03-26T14:31:44Z | |
Document date | 2023 | |
Citation | COSTA, Maria da Conceição N. et al. Causes of death in children with congenital Zika syndrome in Brazil, 2015 to 2018: a nationwide record linkage study. Plos Medicine, v. 20, n. 2, p.1-17, 2023. | en_US |
ISSN | 1549-1676 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/63216 | |
Sponsorship | Secretary of Health Surveillance, Ministry of Health of Brazil.
Wellcome Trust.
European Union Horizon 2020 Research and Innovation Program . | en_US |
Language | eng | en_US |
Publisher | Public Library of Science | en_US |
Rights | open access | en_US |
Subject in Portuguese | Zika virus | en_US |
Subject in Portuguese | Anormalidades congênitas | en_US |
Subject in Portuguese | Doenças do sistema nervoso central | en_US |
Subject in Portuguese | Recém-nascido | en_US |
Subject in Portuguese | Doenças parasitárias | en_US |
Subject in Portuguese | Infecções respiratórias | en_US |
Title | Causes of death in children with congenital Zika syndrome in Brazil, 2015 to 2018: a nationwide record linkage study | en_US |
Type | Article | en_US |
DOI | 10.1371/journal. pmed.1004181 | |
Abstract | Background: Children with congenital Zika syndrome (CZS) have severe damage to the peripheral and central nervous system (CNS), greatly increasing the risk of death. However, there is no information on the sequence of the underlying, intermediate, immediate, and contributing causes of deaths among these children. The aims of this study are describe the sequence of events leading to death of children with CZS up to 36 months of age and their probability of dying from a given cause, 2015 to 2018. Methods and findings: In a population-based study, we linked administrative data on live births, deaths, and cases of children with CZS from the SINASC (Live Birth Information System), the SIM (Mortality Information System), and the RESP (Public Health Event Records), respectively. Confirmed and probable cases of CZS were those that met the criteria established by the Brazilian Ministry of Health. The information on causes of death was collected from death certificates (DCs) using the World Health Organization (WHO) DC template. We estimated proportional mortality (PM%) among children with CZS and among children with non-Zika CNS congenital anomalies (CA) by 36 months of age and proportional mortality ratio by cause (PMRc). A total of 403 children with confirmed and probable CZS who died up to 36 months of age were included in the study; 81.9% were younger than 12 months of age. Multiple congenital malformations not classified elsewhere, and septicemia unspecified, with 18 (PM = 4.5%) and 17 (PM = 4.2%) deaths, respectively, were the most attested underlying causes of death. Unspecified septicemia (29 deaths and PM = 11.2%) and newborn respiratory failure (40 deaths and PM = 12.1%) were, respectively, the predominant intermediate and immediate causes of death. Fetuses and newborns affected by the mother’s infectious and parasitic diseases, unspecified cerebral palsy, and unspecified severe protein-caloric malnutrition were the underlying causes with the greatest probability of death in children with CZS (PMRc from 10.0 to 17.0) when compared to the group born with non-Zika CNS anomalies. Among the intermediate and immediate causes of death, pneumonitis due to food or vomiting and unspecified seizures (PMRc = 9.5, each) and unspecified bronchopneumonia (PMRc = 5.0) were notable. As contributing causes, fetus and newborn affected by the mother’s infectious and parasitic diseases (PMRc = 7.3), unspecified cerebral palsy, and newborn seizures (PMRc = 4.5, each) were more likely to lead to death in children with CZS than in the comparison group. The main limitations of this study were the use of a secondary database without additional clinical information and potential misclassification of cases and controls. Conclusion: The sequence of causes and circumstances involved in the deaths of the children with CZS highlights the greater vulnerability of these children to infectious and respiratory conditions compared to children with abnormalities of the CNS not related to Zika. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil. | en_US |
Affilliation | Goldbelt Professional Services. Chesapeake, Virginia, United States of America. | en_US |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Secretaria Municipal de Saúde. Departamento de Informação em Saúde. Salvador, BA, Brasil | en_US |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil/ Secretaria de Estado de Saúde da Bahia. Centro Regional de Saúde Leste. Santo Antônio de Jesus, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil /Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil / London School of Hygiene and Tropical Medicine. London, United Kingdom. | en_US |
Affilliation | London School of Hygiene and Tropical Medicine. London, United Kingdom. | en_US |
Affilliation | Universidade Federal do Rio Grande do Sul. Departamento de Genética, Porto Alegre, RS, Brasil. | en_US |
Affilliation | London School of Hygiene and Tropical Medicine. London, United Kingdom. | en_US |
Affilliation | Hospital das Forças Armadas do Ministério da Defesa. Diretoria Técnica de Ensino e Pesquisa, Brasília, DF, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil / London School of Hygiene and Tropical Medicine. London, United Kingdom. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Física. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil. | en_US |
Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde. Salvador, BA, Brasil / London School of Hygiene and Tropical Medicine. London, United Kingdom. | en_US |
Subject | Zika virus | en_US |
Subject | Congenital abnormalities | en_US |
Subject | Central nervous system diseases | en_US |
Subject | Infant, newborn | en_US |
Subject | Parasitic diseases | en_US |
Subject | Respiratory tract infections | en_US |
DeCS | Zika virus | en_US |
DeCS | Anormalidades congênitas | en_US |
DeCS | Doenças do sistema nervoso central | en_US |
DeCS | Recém-nascido | en_US |
DeCS | Doenças parasitárias | en_US |
DeCS | Infecções respiratória | en_US |