| Author | Diniz, Clara Pinto | |
| Author | Mediano, Mauro Felippe Felix | |
| Author | Rodrigues Junior, Luiz Fernando | |
| Author | Mendes, Fernanda de Souza Nogueira Sardinha | |
| Author | Saraiva, Roberto Magalhães | |
| Author | Veloso, Henrique Horta | |
| Author | Costa, Andréa Rodrigues da | |
| Author | Hasslocher-Moreno, Alejandro Marcel | |
| Author | Borghi-Silva, Audrey | |
| Author | Sousa, Andrea Silvestre de | |
| Author | Mazzoli-Rocha, Flavia | |
| Access date | 2024-04-13T01:21:50Z | |
| Available date | 2024-04-13T01:21:50Z | |
| Document date | 2024 | |
| Citation | DINIZ, Clara Pinto et al. Inspiratory muscle endurance is similarly reduced in the early and late stages of chronic Chagas heart disease. Tropical Medicine & International Health, v. 29, n. 5, p. 1-9, May 2024. | en_US |
| ISSN | 1360-2276 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/63489 | |
| Sponsorship | The Carlos Chagas Filho Rio de Janeiro State Research Supporting Foundation, Grant/Award Number: ARC/2019. | en_US |
| Sponsorship | This study is linked to the Postgraduate Program in INI/Fiocruz, which is supported clinically and logistically. This study was supported by The Carlos Chagas Filho Rio de Janeiro State Research Supporting Foundation (FAPERJ – ARC/2019). The founders played no role in this study’s design, conduct, or reporting. | |
| Language | eng | en_US |
| Publisher | Blackwell Science Ltd | en_US |
| Rights | restricted access | |
| Title | Inspiratory muscle endurance is similarly reduced in the early and late stages of chronic Chagas heart disease | en_US |
| Type | Article | |
| DOI | 10.1111/tmi.13984 | |
| Abstract | Objective: Inspiratory muscle strength (IMS) appears to be reduced in subjects with chronic Chagas heart disease (CHD), especially in the presence of heart failure (HF). However, only one study about IMS and inspiratory muscle endurance (IME) in those with CHD without heart failure is available. This study aimed to compare IMS and IME in subjects with CHD in the presence and absence of HF. Methods: This is a cross-sectional study in which 30 CHD adult patients were divided into CHD-CC group (initial phase of CHD, without HF; n = 15) and CHD-HF group (advanced phase of CHD, with HF; n = 15). We assessed IMS by maximum inspiratory pressure (MIP) and IME by incremental (Pthmax) and constant load (TLim) tests. Reduced IMS and IME were considered by predicted MIP values <70% and Pthmax/MIP <75%, respectively. Results: Inspiratory muscle weakness (IMW) was more frequent in CHD-HF than in CHD-CC (46.7% vs. 13.3%; p = 0.05), and both groups had high frequencies of reduced IME (93.3% CHD-CC vs. 100.0% CHD-HF; p = 0.95). Age-adjusted logistic regression analysis using HF as a dependent variable showed that HF was associated with an increased chance of IMW compared with the CHD-CC group (OR = 7.47; p = 0.03; 95% CI 1.20-46.19). Conclusion: This study suggests that, in patients with CHD, HF is associated with IMW, and that reduction of IME is already present in the initial phase, similar to the advanced phase with HF. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Chagas Disease Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | National Institute of Cardiology. Department of Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Chagas Disease Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Chagas Disease Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Chagas Disease Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Chagas Disease Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Chagas Disease Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Federal University of São Carlos. São Carlos, SP, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Chagas Disease Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Chagas Disease Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Subject | Chagas disease | en_US |
| Subject | Chagas heart disease | en_US |
| Subject | Heart failure | en_US |
| Subject | Inspiratory muscle endurance | en_US |
| Subject | Inspiratory muscle strength | en_US |
| e-ISSN | 1365-3156 | |
| Embargo date | 2030-12-31 | |
