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AuthorCastro Junior, Archimedes Barbosa
AuthorHorta, Bernardo Coelho
AuthorSantos, Ana Cristina Gomes
AuthorCunha, Andre Pires
AuthorSteinberg, Raphael Silva
AuthorNascimento, Danielle Santiago
AuthorFaria, Ana Maria Caetano de
AuthorVaz, Nelson Monteiro
Access date2013-03-06T13:42:06Z
Available date2013-03-06T13:42:06Z
Document date2012
CitationCASTRO-JUNIOR, Archimedes Barbosa et al. Oral tolerance correlates with high levels of lymphocyte activity. Cell. immunol., New York, v. 280, n. 2, p. 171-181, jan. 2012.
ISSN10.1016/j.cellimm.2012.12.004
URIhttps://www.arca.fiocruz.br/handle/icict/6350
SponsorshipFAPEMIG e CNPqpt_BR
Languageengpt_BR
PublisherAcademic Presspt_BR
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Rightsrestricted access
TitleOral tolerance correlates with high levels of lymphocyte activitypt_BR
TypeArticle
AbstractOral tolerance is defined as an inhibition of specific immune responsiveness to a previously ingested antigen. Paradoxically, we found an increased lymphocyte activity in tolerant mice alongside the specific inhibition. Orally-tolerant mice presented higher number of immunoglobulin secreting cells (ISC) in spleen and bone marrow; showed a greater variety of Ig classes being produced: IgM and IgA in the spleen and IgG and IgM in the bone marrow. ISC from immunized mice produced mainly IgG. Despite having the same number of regulatory and activated T cells in the spleen after immunization, these cells appeared earlier in tolerant mice, right after the primary immunization. Also, tolerant mice showed a prompt expression of regulatory cytokines (TGF-β and IL-10) and a transient expression of effector cytokines (IL-2 and IFN-γ). Thus, in addition to an inhibited specific responsiveness, orally-tolerant mice displayed an early and widespread mobilization of activated and regulatory lymphocytes.pt_BR
AffilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasilpt_BR
AffilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasilpt_BR
AffilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasilpt_BR
AffilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasilpt_BR
AffilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Genética. Belo Horizonte, MG, Brasilpt_BR
AffilliationFundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasilpt_BR
AffilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasilpt_BR
AffilliationUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasilpt_BR
SubjectOral Tolerancept_BR
SubjectLymphocyte Activationpt_BR
SubjectRegulatory T Cellspt_BR
SubjectImmunoglobulin-Secreting Cellspt_BR
SubjectKineticspt_BR
SubjectCytokinespt_BR
DeCSAtivação Linfocitáriapt_BR
DeCSLinfócitos T Reguladorespt_BR
DeCSCélulas Produtoras de Anticorpospt_BR


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