| Author | Costa, Andrea Monte Alto | |
| Author | Pegado, Claudia Schwartz | |
| Author | Porto, Luis Cristovão | |
| Access date | 2013-03-06T16:48:02Z | |
| Available date | 2013-03-06T16:48:02Z | |
| Document date | 1998 | |
| Citation | COSTA, Andrea Monte Alto; PEGADO, Claudia Schwartz; PORTO, Luis Cristovão. Quantification of the intrahepatic biliary tree during human fetal development. Anat. rec., Philadelphia, v. 251, n. 3, p. 297-302, jul. 1998. | pt_BR |
| ISSN | 1097-0185 | |
| URI | https://www.arca.fiocruz.br/handle/icict/6354 | |
| Language | eng | pt_BR |
| Publisher | Wistar Institute of Anatomy and Biology | pt_BR |
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| Rights | restricted access | |
| Title | Quantification of the intrahepatic biliary tree during human fetal development | pt_BR |
| Type | Article | |
| Abstract | Development and differentiation of bile ducts have been studied for the
understanding of pathogenesis of biliary atresia and other diseases of the
intrahepatic biliary tree. The aim of this study is to correlate the type of
biliary structure with the size of the portal tract and the gestational age.
Twenty-four human livers were studied. Fetuses were assigned to four
gestational age groups: group I, up to 20 postfecundation weeks (PFW); group
II, from 21–26 PFW; group III, from 27–32 PFW; and group IV, from 33–38
PFW. In each specimen, 30 portal tracts were classified as small, medium, or
large according to the diameter of the portal vein. In order to identify the bile
duct cells, the sections were immunolabeled with anti-cytokeratin antibody,
and the biliary structure was classified as absent (bile ducts (BD) 5 0),
presence of bile duct cells without lumen (BD 5 1), or presence of bile duct
with lumen (BD 5 2).
In the small portal tracts, either there were no biliary structures or just a
few. There was a substantial increase in the number of medium portal tracts
that included a bile duct as a function of gestational age. The majority of large
portal tracts exhibited a bile duct. In human fetus up to 20 PFW, it is possible
to find 70% of portal tracts without bile ducts, and at 38 PFW it is expected
that more than 50% of the portal tract has a BD . 0.
We suggest the use of the diameter of the portal vein and the gestational
age for the quantification of biliary structures and the evaluation of maturity
of intrahepatic biliary tree. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | Liver Development | pt_BR |
| Subject | Bile Duct | pt_BR |
| Subject | Cytokeratin 19 | pt_BR |
| Subject | Embryology | pt_BR |
| DeCS | Ductos Biliares Intra-Hepáticos | pt_BR |
| DeCS | Desenvolvimento Embrionário e Fetal | pt_BR |
| DeCS | Técnicas Imunoenzimáticas | pt_BR |
| DeCS | Feto | pt_BR |
