Author | Brito, Wagner Izidoro de | |
Author | Oliveira, Rode Martinho de | |
Author | Silva, Jane | |
Author | Tubarão, Luciana Neves | |
Author | Ano Bom, Ana Paula Dinis | |
Author | Melgaço, Juliana Gil | |
Author | Pinto, Marcelo Alves | |
Author | Souto, Francisco José Dutra | |
Access date | 2024-04-25T12:43:50Z | |
Available date | 2024-04-25T12:43:50Z | |
Document date | 2023 | |
Citation | BRITO, Wagner Izidoro de et al. Persistence of immunity against hepatitis A in Brazilian children vaccinated with a single dose of inactivated virus vaccine. Journal of Viral Hepatitis, v. 30, n. 7, p. 579-630, Jul. 2023. | en_US |
ISSN | 1352-0504 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/63693 | |
Language | eng | en_US |
Publisher | Wiley | en_US |
Rights | restricted access | en_US |
Title | Persistence of immunity against hepatitis A in Brazilian children vaccinated with a single dose of inactivated virus vaccine | en_US |
Type | Article | en_US |
DOI | 10.1111/jvh.13819 | |
Abstract | In 2014, the Brazilian National Immunization Program implemented the universal vac-cination against the hepatitis A virus (HAV) for children aged 12 months and older, applying a single dose of the inactivated virus vaccine. It is essential to carry out fol-low-up studies in this population, aiming to verify the longevity of HAV immunological memory. This study evaluated the humoral and cellular immune response of a cohort of children vaccinated between 2014 and 2015, and further investigated between 2015 and 2016, and who had their initial antibody response assessed after the single dose. A second evaluation took place in January 2022. We examined 109 children out of the 252 that took part in the initial cohort. Seventy (64.2%) of them had anti-HAV IgG antibodies. Cellular immune response assays were performed in 37 anti-HAV- negative and 30 anti-HAV- positive children. Production of interferon- gamma (IFN-y) stimulated with the VP1 antigen was demonstrated in 34.3% of these 67 samples. Of the 37 negative anti-HAV samples, 12 (32.4%) produced IFN-y. Among the 30 anti- HAV- positive, 11 (36.7%) produced IFN-y. In total, 82 (76.6%) children presented some type of immune response against HAV. These findings demonstrate the persis-tence of immunological memory against HAV in the majority of children vaccinated between 6 and 7 years with a single dose of the inactivated virus vaccine. | en_US |
Affilliation | Universidade Federal de Mato Grosso. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Empresa Brasileira de Serviços Hospitalares. Cuiabá, MT, Brasil. | en_US |
Affilliation | Secretaria Distrital de Saúde de Primavera do Leste. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos). Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos). Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos). Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos). Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos). Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal de Mato Grosso. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde. Empresa Brasileira de Serviços Hospitalares. Cuiabá, MT, Brasil. | en_US |
Subject | Hepatitis A | en_US |
Subject | Hepatitis A vaccine | en_US |
Subject | Immunity | en_US |
Subject | Immunological memory | en_US |
e-ISSN | 1365-2893 | |
Embargo date | 2030-12-31 | |