| Author | Reis, Erica Guerino dos | |
| Author | Pereira, Sandro Antonio | |
| Author | Miranda, Luisa Helena Monteiro de | |
| Author | Oliveira, Raquel de Vasconcellos Carvalhaes de | |
| Author | Quintana, Marcel de Souza Borges | |
| Author | Viana, Paula Gonçalves | |
| Author | Figueiredo, Anna Barreto Fernandes | |
| Author | Honorato, Cindy Caroline Dos Santos | |
| Author | Pereira-Oliveira, Gabriela Reis | |
| Author | Silva, Jéssica Nunes | |
| Author | Schubach, Tânia Maria Pacheco | |
| Author | Gremião, Isabella Dib Ferreira | |
| Access date | 2024-04-25T23:24:03Z | |
| Available date | 2024-04-25T23:24:03Z | |
| Document date | 2024 | |
| Citation | REIS, Erica Guerino dos et al. A Randomized Clinical Trial Comparing Itraconazole and a Combination Therapy with Itraconazole and Potassium Iodide for the Treatment of Feline Sporotrichosis. Journal of Fungi, v. 10, n. 2, p. 1-15, Jan. 2024. | en_US |
| ISSN | 2309-608X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/63701 | |
| Sponsorship | This work was supported by grants from the Brazilian funding agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq [Gremião IDF, Universal: 478262/2013-2; Schubach TMP: 305669/2012-5], Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro [Reis
EG, PhD scholarship Grade 10: E-26/101.551/2014; Pereira SA, Jovem Cientista do Nosso Estado: E23/102.255/2013; Gremião IDF: E-26/102.422/2013; Schubach TMP, Cientista do Nosso Estado: E26/102251/2009]; Programa Jovens Pesquisadores (INI/Fiocruz): [Gremião IDF: 25029.100173/2019-58], and Coordenação de Aperfeiçoamento da Pessoal de Nível Superior (CAPES). Pereira SA is a recipient of a CNPq productivity fellowship. | en_US |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Title | A Randomized Clinical Trial Comparing Itraconazole and a Combination Therapy with Itraconazole and Potassium Iodide for the Treatment of Feline Sporotrichosis | en_US |
| Type | Article | en_US |
| DOI | 10.3390/jof10020101 | |
| Abstract | Feline sporotrichosis is an endemic disease with high occurrence in Brazil. Itraconazole (ITZ) remains the drug of choice for treating this disease in cats, despite the increasing reports of therapeutic failure. A controlled, randomized clinical trial was performed on 166 naive cats with sporotrichosis to assess the effectiveness and safety of the combination therapy with ITZ and potassium iodide (KI) compared with ITZ monotherapy. Cats were randomly allocated into two treatment groups: G1-ITZ 100 mg/cat/day-and G2-ITZ 100 mg/cat/day + KI 2.5-20 mg/kg/day. Cats treated in G2 presented 77% more risk of reaching a clinical cure (a positive effect) than those treated in G1, even when controlled by negative predictors. The survival curves of the two treatment protocols indicate that a clinical cure was achieved faster in G2. An increase in the KI dose was necessary in 28 cats due to the persistence of clinical signs. Adverse reactions were equally frequent in both groups and manageable with a temporary drug suspension and/or a hepatoprotective therapy. The combination therapy was associated with a higher cure rate and a shorter treatment time, suggesting that ITZ+KI arises as a better option for treating feline sporotrichosis and should be considered the first-line treatment, especially in the presence of negative predictors. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | University of Sydney. Sydney School of Veterinary Science. Sydney, NSW, Australia. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Epidemiology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Epidemiology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Subject | Sporotrichosis | en_US |
| Subject | Sporothrix | en_US |
| Subject | Cats | en_US |
| Subject | Itraconazole | en_US |
| Subject | Potassium iodide | en_US |
| Subject | Treatment | en_US |
| Subject | Combination therapy | en_US |
| e-ISSN | 2309-608X | |
