| Author | Foo, Suan-Sin | |
| Author | Chen, Weiqiang | |
| Author | Chan, Yen | |
| Author | Bowman, James W. | |
| Author | Chang, Lin-Chun | |
| Author | Choi, Younho | |
| Author | Yoo, Ji Seung | |
| Author | Ge, Jianning | |
| Author | Cheng, Genhong | |
| Author | Bonnin, Alexandre | |
| Author | Nielsen-Saines, Karin | |
| Author | Brasil, Patrícia | |
| Author | Jung, Jae U. | |
| Access date | 2024-04-26T00:10:21Z | |
| Available date | 2024-04-26T00:10:21Z | |
| Document date | 2017 | |
| Citation | FOO, Suan-Sin et al. Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy. Nature Microbiology, v. 2, n. 11, p. 1-27, Nov. 2017. | |
| ISSN | 2058-5276 | |
| URI | https://www.arca.fiocruz.br/handle/icict/63707 | |
| Language | eng | en_US |
| Publisher | Nature Publishing Group | |
| Later version | https://www.arca.fiocruz.br/handle/icict/23167 | |
| Rights | open access | |
| Title | Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy | en_US |
| Type | Preprint | |
| DOI | 10.1038/s41564-017-0016-3 | |
| Abstract | Blood CD14+ monocytes are the frontline immunomodulators categorized into classical, intermediate or non-classical subsets, subsequently differentiating into M1 pro- or M2 anti inflammatory macrophages upon stimulation. While Zika virus (ZIKV) rapidly establishes viremia, the target cells and immune responses, particularly during pregnancy, remain elusive. Furthermore, it is unknown whether African- and Asian-lineage ZIKV have different phenotypic impacts on host immune responses. Using human blood infection, we identified CD14+ monocytes as the primary target for African- or Asian-lineage ZIKV infection. When immunoprofiles of human blood infected with ZIKV were compared, a classical/intermediate monocyte-mediated M1-skewed inflammation by African-lineage ZIKV infection was observed, in contrast to a non classical monocyte-mediated M2-skewed immunosuppression by Asian-lineage ZIKV infection. Importantly, infection of pregnant women’s blood revealed enhanced susceptibility to ZIKV infection. Specifically, Asian-lineage ZIKV infection of pregnant women’s blood led to an exacerbated M2-skewed immunosuppression of non-classical monocytes in conjunction with global suppression of type I interferon-signaling pathway and an aberrant expression of host genes associated with pregnancy complications. 30 ZIKV+ sera from symptomatic pregnant patients also showed elevated levels of M2-skewed immunosuppressive cytokines and pregnancy complication associated fibronectin-1. This study demonstrates the differential immunomodulatory responses of blood monocytes, particularly during pregnancy, upon infection with different lineages of ZIKV. | en_US |
| Affilliation | Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA. | |
| Affilliation | Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Obstetrics and Gynecology. Division of Maternal-Fetal Medicine. Los Angeles, CA, USA. | |
| Affilliation | Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Obstetrics and Gynecology. Division of Maternal-Fetal Medicine. Los Angeles, CA, USA. | |
| Affilliation | Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA. | |
| Affilliation | Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA. | |
| Affilliation | Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA. | |
| Affilliation | Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA. | |
| Affilliation | Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA. | |
| Affilliation | University of California. Immunology and Molecular Genetics. Department of Microbiology. Los Angeles, CA, USA. | |
| Affilliation | Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Cell and Neurobiology. Los Angeles, CA, USA. | |
| Affilliation | University of California. David Geffen School of Medicine. Marion Davies Children’s Health Center. Division of Pediatric Infectious Diseases. Los Angeles, CA, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Zilkha Neurogenetic Institute. University of Southern California. Keck School of Medicine. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA. | |
| Subject | Blood CD14+ | en_US |
| Subject | Zika virus (ZIKV) | en_US |
| Subject | African and Asian lineage ZIKV | en_US |
