| Author | Singh, Tej Pratap | |
| Author | Amorim, Camila Farias | |
| Author | Lovins, Victoria M. | |
| Author | Bradley, Charles W. | |
| Author | Carvalho, Lucas P. | |
| Author | Carvalho, Edgar M. | |
| Author | Grice, Elizabeth A. | |
| Author | Scott, Phillip | |
| Access date | 2024-04-30T12:55:16Z | |
| Available date | 2024-04-30T12:55:16Z | |
| Document date | 2023 | |
| Citation | SINGH, Tej Pratap et al. Regulatory T cells control Staphylococcus aureus and disease severity of cutaneous leishmaniasis. Journal of Experimental Medicine, v. 220, n. 12, p. 1-24, 2023. | en_US |
| ISSN | 1540-9538 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/63759 | |
| Sponsorship | National Institutes of Health. | en_US |
| Language | eng | en_US |
| Publisher | Rockefeller University Press | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Células T | en_US |
| Subject in Portuguese | Staphylococcus aureus | en_US |
| Subject in Portuguese | Gravidade da doença | en_US |
| Subject in Portuguese | Leishmaniose cutânea | en_US |
| Title | Regulatory T cells control Staphylococcus aureus and disease severity of cutaneous leishmaniasis | en_US |
| Type | Article | en_US |
| DOI | 10.1084/jem.20230558 | |
| Abstract | Cutaneous leishmaniasis causes alterations in the skin microbiota, leading to pathologic immune responses and delayed healing. However, it is not known how these microbiota-driven immune responses are regulated. Here, we report that depletion of Foxp3+ regulatory T cells (Tregs) in Staphylococcus aureus-colonized mice resulted in less IL-17 and an IFN-γ-dependent skin inflammation with impaired S. aureus immunity. Similarly, reducing Tregs in S. aureus-colonized and Leishmania braziliensis-infected mice increased IFN-γ, S. aureus, and disease severity. Importantly, analysis of lesions from L. braziliensis patients revealed that low FOXP3 gene expression is associated with high IFNG expression, S. aureus burden, and delayed lesion resolution compared to patients with high FOXP3 expression. Thus, we found a critical role for Tregs in regulating the balance between IL-17 and IFN-γ in the skin, which influences both bacterial burden and disease. These results have clinical ramifications for cutaneous leishmaniasis and other skin diseases associated with a dysregulated microbiome when Tregs are limited or dysfunctional. | en_US |
| Affilliation | Department of Pathobiology. School of Veterinary Medicine. University of Pennsylvania. Philadelphia, PA, USA / Department of Dermatology. Perelman School of Medicine. University of Pennsylvania. Philadelphia, PA, USA. | en_US |
| Affilliation | Department of Pathobiology. School of Veterinary Medicine. University of Pennsylvania. Philadelphia, PA, USA. | en_US |
| Affilliation | Department of Dermatology. Perelman School of Medicine. University of Pennsylvania. Philadelphia, PA, USA. | en_US |
| Affilliation | Department of Pathobiology. School of Veterinary Medicine. University of Pennsylvania. Philadelphia, PA, USA. | en_US |
| Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA, Brasil. | en_US |
| Affilliation | Department of Dermatology. Perelman School of Medicine. University of Pennsylvania. Philadelphia, PA, USA | en_US |
| Affilliation | Department of Pathobiology. School of Veterinary Medicine. University of Pennsylvania. Philadelphia, PA, USA. | en_US |
| Subject | T cells | en_US |
| Subject | Staphylococcus aureus | en_US |
| Subject | Disease severity | en_US |
| Subject | Cutaneous leishmaniasis | en_US |
| DeCS | Linfócitos T | en_US |
| DeCS | Staphylococcus aureus | en_US |
| DeCS | Leishmaniose cutânea | en_US |
| DeCS | Gravidade do paciente | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
