| Author | Lago, Tainã | |
| Author | Cardoso, Thyago Marconi | |
| Author | Rocha, Alan | |
| Author | Carvalho, Edgar M. | |
| Author | Castellucci, Léa Cristina | |
| Access date | 2024-05-03T19:29:58Z | |
| Available date | 2024-05-03T19:29:58Z | |
| Document date | 2024 | |
| Citation | LAGO, Tainã et al. Short communication: the miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by Leishmania braziliensis. Plos One, v. 19, n. 2, p. 1-8, Feb. 2024. | en_US |
| ISSN | 1932-6203 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/63869 | |
| Sponsorship | Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT). | en_US |
| Language | eng | en_US |
| Publisher | Public Library of Science | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Comunicação curta | en_US |
| Subject in Portuguese | miR-155a-5p | en_US |
| Subject in Portuguese | ROS | en_US |
| Subject in Portuguese | Apoptose | en_US |
| Subject in Portuguese | Macrófagos infectados | en_US |
| Subject in Portuguese | Leishmania braziliensis | en_US |
| Title | Short communication: the miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by leishmania braziliensis | en_US |
| Type | Article | en_US |
| DOI | 10.1371/journal.pone.0298458 | |
| Abstract | Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis, is a disease characterized by well-limited ulcerated lesions with raised borders in exposed parts of the body. miRNAs are recognized for their role in the complex and plastic interaction between host and pathogens, either as part of the host’s strategy to neutralize infection or as a molecular mechanism employed by the pathogen to modulate host inflammatory pathways to remain undetected. The mir155 targets a broad range of inflammatory mediators, following toll-like receptors (TLRs) signaling. In this work, we evaluated the effects of the expression of miR155a-5p in human macrophages infected with L. braziliensis. Our results show that miR155a-5p is inversely correlated with early apoptosis and conversely, seems to influence an increment in the oxidative burst in these cells. Altogether, we spotted a functional role of the miR155a-5p in CL pathogenesis, raising the hypothesis that an increased miR-155 expression by TLR ligands influences cellular mechanisms settled to promote both killing and control of parasite density after infection. | en_US |
| Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Salvador, BA, Brasil. | en_US |
| Affilliation | Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas (LAPEC). Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas (LAPEC). Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas (LAPEC). Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Programa de Pós-graduação em Ciências da Saúde. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Salvador, BA, Brasil. | en_US |
| Subject | Short communication | en_US |
| Subject | miR-155a-5p | en_US |
| Subject | ROS | en_US |
| Subject | Apoptosis | en_US |
| Subject | Macrophages infected | en_US |
| Subject | Leishmania braziliensis | en_US |
| DeCS | Comunicação | en_US |
| DeCS | Apoptose | en_US |
| DeCS | Macrófagos | en_US |
| DeCS | Leishmania braziliensis | en_US |
