| Author | Machado, Paulo R. L. | |
| Author | Lago, Alexsandro | |
| Author | Cardoso, Thiago M. | |
| Author | Magalhaes, Andréa | |
| Author | Carvalho, Lucas P. | |
| Author | Lago, Tainã | |
| Author | Carvalho, Augusto M. | |
| Author | Costa, Rúbia | |
| Author | Carvalho, Edgar M. | |
| Access date | 2024-05-13T18:28:38Z | |
| Available date | 2024-05-13T18:28:38Z | |
| Document date | 2024 | |
| Citation | MACHADO, Paulo R. L.et al. Disseminated Leishmaniasis, a Severe Form of Leishmania braziliensis Infection. Emerging Infectious Diseases, v. 30, n. 3, p. 1-9, 2024. | en_US |
| ISSN | 1080-6059 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/64029 | |
| Sponsorship | Instituto Nacional de Saúde.
Centro de Pesquisa em Medicina Tropical.
Ministério da Ciência, Tecnologia e Inovação do Brasil.
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). | en_US |
| Language | eng | en_US |
| Publisher | Centers for Disease Control and Prevention | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Brasil | en_US |
| Subject in Portuguese | Leishmania braziliensis | en_US |
| Subject in Portuguese | Leishmaniose cutânea | en_US |
| Subject in Portuguese | Leishmaniose disseminada | en_US |
| Subject in Portuguese | Disseminação de parasitas | en_US |
| Subject in Portuguese | Parasitas | en_US |
| Subject in Portuguese | Terapia para leishmaniose | en_US |
| Title | Disseminated leishmaniasis, a severe form of leishmania braziliensis infection | en_US |
| Type | Article | en_US |
| DOI | 10.3201/eid3003.230786 | |
| Abstract | Disseminated leishmaniasis (DL) is an emergent severe disease manifesting with multiple lesions. To determine the relationship between immune response and clinical and therapeutic outcomes, we studied 101 DL and 101 cutaneous leishmaniasis (CL) cases and determined cytokines and chemokines in supernatants of mononuclear cells stimulated with leishmania antigen. Patients were treated with meglumine antimoniate (20 mg/kg) for 20 days (CL) or 30 days (DL); 19 DL patients were instead treated with amphotericin B, miltefosine, or miltefosine and meglumine antimoniate. High levels of chemokine ligand 9 were associated with more severe DL. The cure rate for meglumine antimoniate was low for both DL (44%) and CL (60%), but healing time was longer in DL (p = 0.003). The lowest cure rate (22%) was found in DL patients with >100 lesions. However, meglumine antimoniate/miltefosine treatment cured all DL patients who received it; therefore, that combination should be considered as first choice therapy. | en_US |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT). Brasília, DF, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | en_US |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT). Brasília, DF, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT). Brasília, DF, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT). Brasília, DF, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Subject | Brazil | en_US |
| Subject | Leishmania braziliensis | en_US |
| Subject | Cutaneous leishmaniasis | en_US |
| Subject | Disseminated leishmaniasis | en_US |
| Subject | Parasite dissemination | en_US |
| Subject | Parasites | en_US |
| Subject | Therapy for leishmaniasis | en_US |
| DeCS | Brasil | en_US |
| DeCS | Leishmania braziliensis | en_US |
| DeCS | Leishmaniose cutânea | en_US |
| DeCS | Parasitos | en_US |
