| Author | Reis, Joice Neves | |
| Author | Azevedo, Jailton | |
| Author | Oliveira, Aisla Mércia Lazaro de | |
| Author | Menezes, Ana Paula de Oliveira | |
| Author | Pedrosa, Mayara | |
| Author | Santos, Milena Soares dos | |
| Author | Ribeiro, Laise Carvalho | |
| Author | Freitas, Humberto Fonseca de | |
| Author | Gouveia, Edilane Lins | |
| Author | Teles, Marcelo Bastos | |
| Author | Carvalho, Maria da Glória | |
| Author | Reis, Mitermayer Galvão | |
| Author | Carvalho, Cristiana Nascimento | |
| Author | Verani, Jennifer R. | |
| Access date | 2024-05-14T15:15:27Z | |
| Available date | 2024-05-14T15:15:27Z | |
| Document date | 2024 | |
| Citation | REIS, Joice Neves et al. Long-term surveillance of invasive pneumococcal disease: the impact of 10-valent pneumococcal conjugate vaccine in the metropolitan region of Salvador, Brazil. Vaccine, v. 42, n. 3, p. 1-15, Jan. 2024. | en_US |
| ISSN | 0264-410X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/64059 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
undação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
Programa Estratégico de Apoio à Pesquisa em Saúde (PAPES).
National Institutes of Health.
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). | en_US |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Doença pneumocócica invasiva | en_US |
| Subject in Portuguese | Vacina pneumocócica conjugada | en_US |
| Subject in Portuguese | Streptococcus pneumoniae | en_US |
| Subject in Portuguese | Vacina pneumocócica conjugada | en_US |
| Title | Long-term surveillance of invasive pneumococcal disease: The impact of 10-valent pneumococcal conjugate vaccine in the metropolitan region of Salvador, Brazil | en_US |
| Type | Article | en_US |
| DOI | 10.1016/j.vaccine.2023.12.055 | |
| Abstract | Background: In 2010, Brazil introduced the ten-valent pneumococcal conjugate vaccine (PCV10) in the national infant immunization program. Limited data on the long-term impact of PCV10 are available from lower-middle-income settings. We examined invasive pneumococcal disease (IPD) in Salvador, Bahia, over 11 years. Methods: Prospective laboratory-based surveillance for IPD was carried out in 9 hospitals in the metropolitan region of Salvador from 2008 to 2018. IPD was defined as Streptococcus pneumoniae cultured from a normally sterile site. Serotype was determined by multiplex polymerase chain reaction and/or Quellung reaction. Incidence rates per 100,000 inhabitants were calculated for overall, vaccine-type, and non-vaccine-type IPD using census data as the denominator. Incidence rate ratios (IRRs) were calculated to compare rates during the early (2010-2012), intermediate (2013-2015), and late (2016-2018) post-PCV10 periods in comparison to the pre-PCV10 period (2008-2009). Results: Pre-PCV10, overall IPD incidence among all ages was 2.48/100,000. After PCV10 introduction, incidence initially increased (early post-PCV10 IRR 3.80, 95% CI 1.18-1.99) and then declined to 0.38/100,000 late post-PCV10 (IRR 0.15; 95% CI 0.09-0.26). The greatest reductions in the late post-PCV10 period were observed in children aged ≤2 years, with no cases (IRR not calculated) and those ≥60 years (IRR 0.11, 95% CI 0.03-0.48). Late post-PCV10, significant reductions were observed for both PCV10 serotypes (IRR 0.02; 95% CI 0.0-0.15) and non-PCV10 serotypes (IRR 0.27; 95%CI 0.14-0.53). Non-PCV10 serotypes 15B, 12F, 3, 17F, and 19A became predominant late post-PCV10 without a significant increase in serotype-specific IPD incidence compared to pre-PCV10. Conclusion: Significant declines in IPD, including among adults not eligible for vaccination, suggest direct and indirect protection up to nine years after PCV10 introduction, without evidence of significant replacement disease. Continued surveillance is needed to monitor changes in non-vaccine serotypes and inform decisions about introducing higher valent PCVs. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz, Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade do Estado da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Campus Anísio Teixeira. Vitória da Conquista, BA, Brasil. | en_US |
| Affilliation | Secretaria de Saúde do Estado da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Secretaria de Saúde do Estado da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Secretaria de Saúde do Estado da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Centers for Disease Control and Prevention. Division of Bacterial Diseases. Atlanta, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases. School of Public Health. Yale School of Public Health. Yale University. New Haven, CT, USA. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Centers for Disease Control and Prevention. Division of Bacterial Diseases. Atlanta, USA. | en_US |
| Subject | Invasive pneumococcal disease | en_US |
| Subject | Pneumococcal conjugate vaccine | en_US |
| Subject | Streptococcus pneumoniae | en_US |
| Subject | Valent pneumococcal conjugate vaccine | en_US |
| DeCS | Infecções pneumocócicas | en_US |
| DeCS | Vacinas pneumocócicas | en_US |
| DeCS | Streptococcus pneumoniae | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
