| Author | Nonaka, Carolina Kymie Vasques | |
| Author | Ribeiro, Adlas Michel de Jesus | |
| Author | Rocha, Gisele Vieira | |
| Author | Hora, Helena Souza da | |
| Author | Fonseca Junior, Antônio Augusto | |
| Author | Lima, Fernanda de Macêdo | |
| Author | Bastos, Iasmin Nogueira | |
| Author | Teles, Samara Alves Sá | |
| Author | Weber, Thamires Gomes Lopes | |
| Author | Costa, Vanessa Ferreira | |
| Author | Costa-Ferro, Zaquer Suzana | |
| Author | Rocha, Clarissa Araújo Gurgel | |
| Author | Sardi, Silvia Inês | |
| Author | Soares, Gúbio | |
| Author | Mendes, Ana Verena Almeida | |
| Author | Souza, Bruno Solano de Freitas | |
| Access date | 2024-05-20T14:01:50Z | |
| Available date | 2024-05-20T14:01:50Z | |
| Document date | 2024 | |
| Citation | NONAKA, Carolina Kymie Vasques et al. Assessing the clinical impact of the SARS-CoV-2 gamma variant on intensive care unit admissions: insights from a reference hospital in northeastern brazil. Viruses, v. 16, n. 3, p. 1-13, 2024. | en_US |
| ISSN | 1999-4915 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/64132 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Programa Inova Fiocruz - COVID-19.
Fundação Maria Emília. | en_US |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | SARS-CoV-2 | en_US |
| Subject in Portuguese | Gama | en_US |
| Subject in Portuguese | Doença por coronavírus-19 (COVID-19) | en_US |
| Title | Assessing the clinical impact of the SARS-CoV-2 gamma variant on intensive care unit admissions: insights from a reference hospital in Northeastern Brazil. | en_US |
| Type | Article | en_US |
| DOI | 10.3390/v16030467 | |
| Abstract | The global challenge posed by the prolonged COVID-19 pandemic underscores the critical need for ongoing genomic surveillance to identify emerging variants and formulate effective public health strategies. This retrospective observational study, conducted in a reference hospital in Northeast Brazil and comprising 2116 cases, employed PCR genotyping together with epidemiological data to elucidate the impact of the Gamma variant during its emergence, revealing distinct patterns in hospitalization rates, severity of illness, and outcomes. The study emphasizes the challenges posed by the variant, particularly an increased tendency for ICU admissions and respiratory support, especially among adults aged 18 to 59 without comorbidities. Laboratory analyses further demonstrate elevated inflammatory, coagulation, and hepatic markers in the Gamma variant cohort, suggesting a more severe systemic response. Despite limitations, including a retrospective approach and single-institution data, the study underscores the importance of ongoing genomic surveillance. Overall, this research contributes valuable insights into the impact of the Gamma variant on COVID-19 dynamics, advocating for continued research and surveillance to inform effective public health strategies regarding evolving viral variants. | en_US |
| Affilliation | Instituto D’Or de Pesquisa e Ensino (IDOR). Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Instituto D’Or de Pesquisa e Ensino (IDOR). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Laboratório Nacional Agropecuário. MAPA. Pedro Leopoldo, MG, Brasil. | en_US |
| Affilliation | Faculdade Bahiana de Medicina Salvador. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Medicina e Odontologia. Salvador, BA, Brasil. | en_US |
| Affilliation | Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Instituto D’Or de Pesquisa e Ensino (IDOR). Salvador, BA, Brasil. | en_US |
| Affilliation | Instituto D’Or de Pesquisa e Ensino (IDOR). Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina e Odontologia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Hospital São Rafael. Salvador, BA, Brasil. | en_US |
| Affilliation | Instituto D’Or de Pesquisa e Ensino (IDOR). Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | Gamma | en_US |
| Subject | Coronavirus disease-19 (COVID-19) | en_US |
| DeCS | SARS-CoV-2 | en_US |
| DeCS | COVID-19 | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
