| Author | Passos, Beatriz B. S. | |
| Author | Pereira, Mariana Araújo | |
| Author | Vinhaes, Caian L. | |
| Author | Amaral, Eduardo P. | |
| Author | Andrade, Bruno B. | |
| Access date | 2024-05-20T17:07:35Z | |
| Available date | 2024-05-20T17:07:35Z | |
| Document date | 2024 | |
| Citation | PASSOS, Beatriz B. S. et al. The role of ESAT-6 in tuberculosis immunopathology. Frontiers in Immunology, v. 15, p. 1-11, 2024. | en_US |
| ISSN | 1664-3224 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/64137 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Programa de Investigação Intramural da Fundação Oswaldo Cruz.
Programa de Investigação Intramural da Fundação José Silveira.
Departamento de Ciência e Tecnologia.
Institutos Nacionais de Alergia e Doenças Infecciosas. | en_US |
| Language | eng | en_US |
| Publisher | Frontiers Media | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Tuberculose | en_US |
| Subject in Portuguese | ESAT-6 | en_US |
| Subject in Portuguese | Ativação imunológica | en_US |
| Subject in Portuguese | Morte celular | en_US |
| Subject in Portuguese | Imunopatologia | en_US |
| Title | The role of ESAT-6 in tuberculosis immunopathology | en_US |
| Type | Article | en_US |
| DOI | 10.3389/fimmu.2024.1383098 | |
| Abstract | Despite major global efforts to eliminate tuberculosis, which is caused by Mycobacterium tuberculosis (Mtb), this disease remains as a major plague of humanity. Several factors associated with the host and Mtb interaction favor the infection establishment and/or determine disease progression. The Early Secreted Antigenic Target 6 kDa (ESAT-6) is one of the most important and well-studied mycobacterial virulence factors. This molecule has been described to play an important role in the development of tuberculosis-associated pathology by subverting crucial components of the host immune responses. This review highlights the main effector mechanisms by which ESAT-6 modulates the immune system, directly impacting cell fate and disease progression. | en_US |
| Affilliation | Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade Zarns, Clariens Educação. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil. | en_US |
| Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade Zarns, Clariens Educação. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil. | en_US |
| Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade Zarns, Clariens Educação. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública (EBMSP). Programa de Pós-graduação em Medicina e Saúde Humana. Salvador, BA, Brasil / Universidade de São Paulo. Faculdade de Medicina. Departamento de Infectologia, Hospital das Clínicas. São Paulo, SP, Brasil. | en_US |
| Affilliation | Inflammation and Innate Immunity Unit. Laboratory of Clinical Immunology & Microbiology. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, MD, United States. | en_US |
| Affilliation | Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade Zarns, Clariens Educação. Instituto de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública (EBMSP). Programa de Pós-graduação em Medicina e Saúde Humana. Salvador, BA, Brasil. | en_US |
| Subject | Tuberculosis | en_US |
| Subject | ESAT-6 | en_US |
| Subject | Immune activation | en_US |
| Subject | Cell death | en_US |
| Subject | Immunopathology | en_US |
| DeCS | Tuberculose | en_US |
| DeCS | Morte celular | en_US |
