| Author | Rocha, Leonardo de Oliveira Siquara da | |
| Author | Morais, Everton Freitas de | |
| Author | Oliveira, Lilianny Querino Rocha de | |
| Author | Barbosa, Andressa Vollono | |
| Author | Lambert, Daniel W. | |
| Author | Rocha, Clarissa A. Gurgel | |
| Author | Coletta, Ricardo D. | |
| Access date | 2024-05-21T13:19:34Z | |
| Available date | 2024-05-21T13:19:34Z | |
| Document date | 2024 | |
| Citation | ROCHA, Leonardo de Oliveira Siquara da et al. Exploring beyond common cell death pathways in oral cancer: a systematic review. Biology, v. 13, n. 2, p.1-50, 2024. | en_US |
| ISSN | 2079-7737 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/64158 | |
| Sponsorship | Academy of Medical Sciences/Newton Advanced Fellowship Grant.
Programa de Excelência em Pesquisa da Fundação Oswaldo Cruz (PROEP-FIOCRUZ-BA).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). | en_US |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Tipos emergentes de morte celular | en_US |
| Subject in Portuguese | Microambiente tumoral | en_US |
| Subject in Portuguese | Câncer bucal | en_US |
| Subject in Portuguese | Ferroptose | en_US |
| Subject in Portuguese | Piroptose | en_US |
| Subject in Portuguese | Necroptose | en_US |
| Subject in Portuguese | Revisão sistemática | en_US |
| Title | Exploring beyond common cell death pathways in oral cancer: a systematic review | en_US |
| Type | Article | en_US |
| DOI | 10.3390/biology13020103 | |
| Abstract | Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head and neck cancer in the world. Variable response and acquisition of resistance to traditional therapies show that it is essential to develop novel strategies that can provide better outcomes for the patient. Understanding of cellular and molecular mechanisms of cell death control has increased rapidly in recent years. Activation of cell death pathways, such as the emerging forms of non-apoptotic programmed cell death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis and paraptosis, may represent clinically relevant novel therapeutic opportunities. This systematic review summarizes the recently described forms of cell death in OSCC, highlighting their potential for informing diagnosis, prognosis and treatment. Original studies that explored any of the selected cell deaths in OSCC were included. Electronic search, study selection, data collection and risk of bias assessment tools were realized. The literature search was carried out in four databases, and the extracted data from 79 articles were categorized and grouped by type of cell death. Ferroptosis, pyroptosis, and necroptosis represented the main forms of cell death in the selected studies, with links to cancer immunity and inflammatory responses, progression and prognosis of OSCC. Harnessing the potential of these pathways may be useful in patient-specific prognosis and individualized therapy. We provide perspectives on how these different cell death types can be integrated to develop decision tools for diagnosis, prognosis, and treatment of OSCC. | en_US |
| Affilliation | Universidade Federal da Bahia. da Faculdade de Medicina Departamento de Patologia e Medicina Legal. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade de Campinas. da Faculdade de Odontologia. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil. | en_US |
| Affilliation | Universidade de Campinas. da Faculdade de Odontologia. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | School of Clinical Dentistry. The University of Sheffield. Sheffield, UK. | en_US |
| Affilliation | Universidade Federal da Bahia. da Faculdade de Medicina Departamento de Patologia e Medicina Legal. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Odontologia. Departamento de Propedêutica. Salvador, BA, Brasil / Instituto D’Or de Pesquisa e Ensino (IDOR). Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade de Campinas. da Faculdade de Odontologia. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil. | en_US |
| Subject | Emerging types of cell death | en_US |
| Subject | Tumor microenvironment | en_US |
| Subject | Oral cancer | en_US |
| Subject | Ferroptosis | en_US |
| Subject | Pyroptosis | en_US |
| Subject | Necroptosis | en_US |
| Subject | Systematic review | en_US |
| DeCS | Morte celular | en_US |
| DeCS | Microambiente tumoral | en_US |
| DeCS | Neoplasias bucais | en_US |
| DeCS | Ferroptose | en_US |
| DeCS | Piroptose | en_US |
| DeCS | Necroptose | en_US |
| DeCS | Revisão sistemática | en_US |
