| Author | Corrêa-Castro, Gabriela | |
| Author | Silva-Freitas, Maria Luciana | |
| Author | Paula, Ludmila de | |
| Author | Pereira, Leonardo Soares | |
| Author | Dutra, Maria Rita Teixeira | |
| Author | Albuquerque, Hermano Gomes | |
| Author | Cota, Glaucia Fernandes | |
| Author | Martins, Caroline de Azevedo | |
| Author | Da-Cruz, Alda Maria | |
| Author | Gomes-Silva, Adriano | |
| Author | Santos-Oliveira, Joanna Reis | |
| Access date | 2024-06-05T15:39:36Z | |
| Available date | 2024-06-05T15:39:36Z | |
| Document date | 2024 | |
| Citation | CORRÊA-CASTRO, Gabriela et al. A link between circulating immune complexes and acute kidney injury in human visceral leishmaniasis. Scientifc Reports, v. 14, n. 9870, p. 1-14, Apr. 2024. | en_US |
| ISSN | 2045-2322 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/64323 | |
| Sponsorship | This work was supported by the Instituto Oswaldo Cruz (internal funds: PAEF II-IOC-23-FIO-18–2-53), CNPq (Universal—433637/2018–8), FAPERJ (E-26/202.944/2016) and IFRJ (Pro-Ciência/2019-2022). MLS-F received a fellowship from CAPES. GC-C received a fellowship from FAPERJ. AMD-C receive research fellowships from CNPq and FAPERJ. GC is currently receiving a grant from CNPq [302069/2022]. Te funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | |
| Language | eng | en_US |
| Publisher | Nature | en_US |
| Rights | open access | |
| Title | A link between circulating immune complexes and acute kidney injury in human visceral leishmaniasis | en_US |
| Type | Article | |
| DOI | 10.1038/s41598-024-60209-0 | |
| Abstract | Visceral leishmaniasis (VL) is an infectious disease caused by Leishmania infantum. Clinically, VL evolves with systemic impairment, immunosuppression and hyperactivation with hypergammaglobulinemia. Although renal involvement has been recognized, a dearth of understanding about the underlying mechanisms driving acute kidney injury (AKI) in VL remains. We aimed to evaluate the involvement of immunoglobulins (Igs) and immune complexes (CIC) in the occurrence of AKI in VL patients. Fourteen VL patients were evaluated between early treatment and 12 months post-treatment (mpt). Anti-Leishmania Igs, CIC, cystatin C, C3a and C5a were assessed and correlated with AKI markers. Interestingly, high levels of CIC were observed in VL patients up to 6 mpt. Concomitantly, twelve patients met the criteria for AKI, while high levels of cystatin C were observed up to 6 mpt. Plasmatic cystatin C was positively correlated with CIC and Igs. Moreover, C5a was correlated with cystatin C, CIC and Igs. We did not identify any correlation between amphotericin B use and kidney function markers in VL patients, although this association needs to be further explored in subsequent studies. Our data reinforce the presence of an important renal function impairment during VL, suggesting the involvement of Igs, CIC, and C5a in this clinical condition. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro. Núcleo de Ciências Biomédicas Aplicadas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Universidade Estadual do Rio de Janeiro. Faculdade de Ciências Médicas. Rio de Janeiro, RJ, Brasil / Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro. Rede de Pesquisas em Saúde. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Instituto Federal de Educação, Ciência e Tecnologia. Núcleo de Ciências Biomédicas Aplicadas. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Visceral leishmaniasis (VL) | |
| Subject | Leishmania infantum | |
| Subject | Amphotericin B | |
| Subject | Renal function impairment | |
| e-ISSN | 2045-2322 | |
