| Autor | Magalhaes, Giselle Santos | |
| Autor | Gregorio, Juliana Fabiana | |
| Autor | Beltrami, Vinicius Amorim | |
| Autor | Felix, Franciel Batista | |
| Autor | Oliveira-Campos, Livia | |
| Autor | Bonilha, Caio Santos | |
| Autor | Righetti, Renato Fraga | |
| Autor | Tibério, Iolanda de Fátima Lopes Calvo | |
| Autor | Sousa, Frederico B De | |
| Autor | Rezende, Barbara Maximino | |
| Autor | Carvalho, Andréa Teixeira de | |
| Autor | Santos, Robson As | |
| Autor | Campagnole-Santos, Maria José | |
| Autor | Rodrigues-Machado, Maria da Gloria | |
| Autor | Teixeira, Mauro Martins | |
| Autor | Pinho, Vanessa | |
| Data de acesso | 2024-06-06T16:05:12Z | |
| Data de disponibilização | 2024-06-06T16:05:12Z | |
| Data do publicação | 2024 | |
| Citação | MAGALHAES, Giselle Santos et al. A single dose of angiotensin-(1-7) resolves eosinophilic inflammation and protects the lungs from a secondary inflammatory challenge. Inflamm Res., v. 73, n. 6, 1019-1031, 2024. doi: 10.1007/s00011-024-01880-x | en_US |
| ISSN | 1420-908X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/64340 | |
| Idioma | eng | en_US |
| Editor | Birkhäuser | en_US |
| Direito Autoral | restricted access | |
| Título | A single dose of angiotensin-(1-7) resolves eosinophilic inflammation and protects the lungs from a secondary inflammatory challenge. | en_US |
| Tipo do documento | Article | |
| Resumo em Inglês | Objective: Angiotensin-(1-7) [Ang-(1-7)] is a pro-resolving mediator. It is not known whether the pro-resolving effects of Ang-(1-7) are sustained and protect the lung from a subsequent inflammatory challenge. This study sought to investigate the impact of treatment in face of a second allergic or lipopolysaccharide (LPS) challenge.
Methods: Mice, sensitized and challenged with ovalbumin (OVA), received a single Ang-(1-7) dose at the peak of eosinophilic inflammation, 24 h after the final OVA challenge. Subsequently, mice were euthanized at 48, 72, 96, and 120 h following the OVA challenge, and cellular infiltrate, inflammatory mediators, lung histopathology, and macrophage-mediated efferocytic activity were evaluated. The secondary inflammatory stimulus (OVA or LPS) was administered 120 h after the last OVA challenge, and subsequent inflammatory analyses were performed.
Results: Treatment with Ang-(1-7) resulted in elevated levels of IL-10, CD4+Foxp3+, Mres in the lungs and enhanced macrophage-mediated efferocytic capacity. Moreover, in allergic mice treated with Ang-(1-7) and then subjected to a secondary OVA challenge, inflammation was also reduced. Similarly, in mice exposed to LPS, Ang-(1-7) effectively prevented the lung inflammation.
Conclusion: A single dose of Ang-(1-7) resolves lung inflammation and protect the lung from a subsequent inflammatory challenge highlighting its potential therapeutic for individuals with asthma. | en_US |
| Afiliação | René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Department of Physiology and Biophysics. National Institute of Science and Technology in Nanobiopharmaceutics. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Department of Morphology. Biological Sciences Institute. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Department of Morphology. Biological Sciences Institute. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Medical Sciences Faculty of Minas Gerais. Post-Graduate Program in Health Sciences. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Center for Research in Inflammatory Diseases. University of São Paulo. São Paulo, SP, Brazil/Institute of Infection, Immunity and Inflammation. University of Glasgow. Glasgow, UK. | en_US |
| Afiliação | Faculty of Medicine. University of São Paulo. São Paulo, SP, Brazil/Rehabilitation Service. Hospital Sírio-Libanês. São Paulo, SP, Brazil. | en_US |
| Afiliação | Rehabilitation Service. Hospital Sírio-Libanês. São Paulo, SP, Brazil. | en_US |
| Afiliação | Laboratory of Polymeric and Supramolecular Systems. Institute of Physics and Chemistry. Federal University of Itajuba. Itajubá, MG, Brazil. | en_US |
| Afiliação | Department of Basic Nursing, School of Nursing, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Department of Physiology and Biophysics. National Institute of Science and Technology in Nanobiopharmaceutics. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Department of Physiology and Biophysics. National Institute of Science and Technology in Nanobiopharmaceutics. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Medical Sciences Faculty of Minas Gerais. Post-Graduate Program in Health Sciences. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Department of Biochemistry and Immunology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Department of Morphology. Biological Sciences Institute. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil | en_US |
| Palavras-chave em inglês | Ang-(1–7) | en_US |
| Palavras-chave em inglês | Chronic inflammation | en_US |
| Palavras-chave em inglês | Eosinophil | en_US |
| Palavras-chave em inglês | Inflammation | en_US |
| Palavras-chave em inglês | Resolution of inflammation | en_US |
| Data de embargo | 3100-12-31 | |
