| Author | Santos, Ronald Alves dos | |
| Author | Queiroz, Lorena Conceição de | |
| Author | Costa, Fernanda Freitas | |
| Author | Santos, Keila Ramos dos | |
| Author | Jesus, Kelvin Edson M. de | |
| Author | Silva, Thairone M. da | |
| Author | Costa, Yuri Tabajara Pereira | |
| Author | Macedo, Michael N. | |
| Author | Fialho, Thainá Rodrigues de S. | |
| Author | Oliveira, Bruna Souza S. | |
| Author | Casaes, Ane Caroline | |
| Author | Costa, Bernardo G. G. | |
| Author | Francisco, Marcos Vinicius L. de O. | |
| Author | Siqueira, Isadora Cristina de | |
| Author | Oliveira, Ricardo Riccio | |
| Access date | 2024-06-17T14:28:10Z | |
| Available date | 2024-06-17T14:28:10Z | |
| Document date | 2022 | |
| Citation | SANTOS, Ronald Alves dos et al. Reinfection by Schistosoma mansoni one year after mass drug administration of praziquantel in a high endemicity rural area of the state of Bahia, Brazil. In: SIMPÓSIO INTERNACIONAL SOBRE ESQUISTOSSOMOSE, 16, 2022, Ouro Preto, MG. Anais eletrônicos [...] Ouro Preto, MG: Fiocruz, 21 a 23 de novembro de 2022. p.1. | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/64510 | |
| Sponsorship | Fundação Oswaldo Cruz (FIOCRUZ), Instituto Gonçalo Moniz (IGM).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). | en_US |
| Language | eng | en_US |
| Publisher | FIOCRUZ | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Reinfecção | en_US |
| Subject in Portuguese | Schistosoma mansoni | en_US |
| Subject in Portuguese | Administração de medicamento | en_US |
| Subject in Portuguese | Praziquantel | en_US |
| Subject in Portuguese | Endemia | en_US |
| Subject in Portuguese | Área rural | en_US |
| Subject in Portuguese | Bahia, Brasil | en_US |
| Title | Reinfection by Schistosoma mansoni one year after mass drug administration of praziquantel in a high endemicity rural area of the state of Bahia, Brazil | en_US |
| Type | Papers presented at events | en_US |
| Abstract | INTRODUCTION: Schistosomiasis is a global public health problem related to poverty. Factors such as lack of sanitation and family income contribute to the transmission and maintenance of the disease in poor regions. In this study, we evaluated socioeconomic parameters associated with Schistosoma mansoni infection in an endemic rural area of the state of Bahia, Brazil submitted to mass drug administration (MDA) of praziquantel over one year after treatment. METHODOLOGY: This cohort included all habitants of three villages in the rural area of Conde-Bahia-Brazil. All participants provided stool samples for Kato-Katz (KK). After baseline (D0) evaluation praziquantel (PZQ) was administered for all participants and they were then followed up and re-evaluated at 30 (D30), 180 (D180) and 360 (D360) days after treatment. RESULTS: A total of 340 individuals were included in D0, of which 55.6% (n=189) were positive for S. mansoni in the Kato-Katz. Most of the infected individuals (73.5%) showed a low parasite burden (1-99 epg). Considering the high KK positivity observed in baseline, participants underwent mass drug administration (MDA) with praziquantel (PZQ). Thirty days after PZQ treatment KK positivity reduced from 55.6% to 3.0%. At D180 and D360 the positivity of KK increased to 5.5% and 16.5%, respectively. Regarding socioeconomic conditions, 24.8% of included families do not have bathrooms at home, and 13.8% send their waste to the river or its surroundings. Considering the families that have bathrooms at home, 84.1% use a septic tank as a sanitary sewage system. Regarding family income, 84.6% of included individuals received less than one minimum wage. A questionnaire to assess the contact with local water bodies was applied and showed that 93.5% of included participants related contact with water in D0. Six months after treatment 66.7% related contact with water and one year after treatment the frequency of individuals who related contact with local water bodies was 77.1%. CONCLUSION: In this study, we describe a region with high prevalence of Schistosoma infection, with the predominance of low parasite burden. Mass drug administration of PZQ was able to significantly reduce the number of individuals positive for KK thirty days after treatment. However, since PZQ is not effective in preventing reinfections or against larval forms of Schistosoma, this number goes up again at six and twelve months after PZQ administration. The lack of basic sanitation and dependence of local water bodies for domestic and economic activities are the likely factors responsible for the maintenance of schistosomiasis in the region, even after the treatment of the population. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. | en_US |
| Subject | Reinfection | en_US |
| Subject | Schistosoma mansoni | en_US |
| Subject | Drug administration | en_US |
| Subject | Praziquantel | en_US |
| Subject | Endemia | en_US |
| Subject | Rural area | en_US |
| Subject | Bahia, Brazil | en_US |
| DeCS | Reinfecção | en_US |
| DeCS | Schistosoma mansoni | en_US |
| DeCS | Praziquantel | en_US |
| DeCS | Doenças endêmicas | en_US |
| DeCS | Zona rural | en_US |
| DeCS | Brasil | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 11 Cidades e comunidades sustentáveis | |
