| Author | Queto, Túlio | |
| Author | Vasconcelos, Zilton Farias Meira de | |
| Author | Luz, Ricardo Alves | |
| Author | Anselmo, Carina | |
| Author | Guiné, Ana Amélia A. | |
| Author | Silva, Patricia Machado R. | |
| Author | Farache, Júlia | |
| Author | Cunha, José Marcos T. | |
| Author | Bonomo, Adriana C. | |
| Author | Elsas, Maria Ignez Capella Gaspar | |
| Author | Xavier-Elsas, Pedro Paulo | |
| Access date | 2013-04-17T14:56:35Z | |
| Available date | 2013-04-17T14:56:35Z | |
| Document date | 2011 | |
| Citation | QUETO, Tulio et al. G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production. Life Science, Oxford, v. 88, n. 19-20, 2011. | pt_BR |
| ISSN | 2252-6277 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/6456 | |
| Sponsorship | INCA, CNPq, FIOCRUZ | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier Science | pt_BR |
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| Rights | restricted access | |
| Title | G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.lfs.2011.03.001 | |
| Abstract | AIMS: Granulocyte Colony-Stimulating Factor (G-CSF), which mobilizes hemopoietic stem cells (HSC), is believed to protect HSC graft recipients from graft-versus-host disease by enhancing Th2 cytokine secretion. Accordingly, G-CSF should aggravate Th2-dependent allergic pulmonary inflammation and the associated eosinophilia. We evaluated the effects of G-CSF in a model of allergic pulmonary inflammation. MAIN METHODS: Allergic pulmonary inflammation was induced by repeated aerosol allergen challenge in ovalbumin-sensitized C57BL/6J mice. The effects of allergen challenge and of G-CSF pretreatment were evaluated by monitoring: a) eosinophilia and cytokine/chemokine content of bronchoalveolar lavage fluid, pulmonary interstitium, and blood; b) changes in airway resistance; and c) changes in bone-marrow eosinophil production. KEY FINDINGS: Contrary to expectations, G-CSF pretreatment neither induced nor enhanced allergic pulmonary inflammation. Instead, G-CSF: a) suppressed accumulation of infiltrating eosinophils in bronchoalveolar, peribronchial and perivascular spaces of challenged lungs; and b) prevented ovalbumin challenge-induced rises in airway resistance. G-CSF had multiple regulatory effects on cytokine and chemokine production: in bronchoalveolar lavage fluid, levels of IL-1 and IL-12 (p40), eotaxin and MIP-1a were decreased; in plasma, KC, a neutrophil chemoattractant, was increased, while IL-5 was decreased and eotaxin was unaffected. In bone-marrow, G-CSF: a) prevented the increase in bone-marrow eosinophil production induced by ovalbumin challenge of sensitized mice; and b) selectively stimulated neutrophil colony formation. SIGNIFICANCE: These observations challenge the view that G-CSF deviates cytokine production towards a Th2 profile in vivo, and suggest that this neutrophil-selective hemopoietin affects eosinophilic inflammation by a combination of effects on lung cytokine production and bone-marrow hemopoiesis. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Nacional do Câncer. Divisão de Medicina Experimental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil / Instituto Nacional do Câncer. Divisão de Medicina Experimental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Eosinophils | pt_BR |
| Subject | Granulocyte Colony-Stimulating Factor | pt_BR |
| Subject | Th1–Th2 balance | pt_BR |
| Subject | Experimental Therapies | pt_BR |
| DeCS | Quimiocinas | pt_BR |
| DeCS | Citocinas | pt_BR |
| DeCS | Regulação para Baixo | pt_BR |
| DeCS | Fator Estimulador de Colônias de Granulócitos | pt_BR |
| DeCS | Pneumonia - prevenção & controle | pt_BR |
