| Author | Matos, D. D. S. B. | |
| Author | Soares, I. C. M. P. | |
| Author | Nascimento, M. T. | |
| Author | Santos, A. R. dos | |
| Author | Carvalho, L. | |
| Author | Carvalho Filho, E. M. de | |
| Author | Cardoso, T. M. D. S. | |
| Access date | 2024-07-04T17:43:17Z | |
| Available date | 2024-07-04T17:43:17Z | |
| Document date | 2023 | |
| Citation | MATOS, D. D. S. B. et al. Measles, rubella and mumps particles are capable of inducing B cells proliferation from SARS-CoV2 convalescent or vaccinated individuals. In: CONGRESS OF THE BRAZILIAN SOCIETY OF IMMUNOLOGY, 46, 2023, Ouro Preto, MG. Anais eletrônicos [...] Ouro Preto, MG: SBI, 02 a 6 de outubro de 2023. p.1-33. | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/64845 | |
| Language | eng | en_US |
| Publisher | Sociedade Brasileira de Imunologia | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | SARS-CoV-2 | en_US |
| Subject in Portuguese | Células B | en_US |
| Subject in Portuguese | MMR | en_US |
| Title | Measles, rubella and mumps particles are capable of inducing B cells proliferation from SARS-CoV2 convalescent or vaccinated individuals | en_US |
| Type | Papers presented at events | en_US |
| Abstract | Introduction: Cross-reactivity caused by similar viral antigens leading antibody production are observe in several pathologies including SARS-CoV2 infection. This seems to occur with the measles, rubella and mumps viruses contained in the MMR vaccine. The cross-reactivity MMR immunization within SARS-CoV2 antigens may be an alternative vaccine complement to specific vaccines for SARS-CoV2. Objective: To investigate the ability of MMR antigens to induce the proliferation of B cells able to produce antibodies against SARS-CoV2 antigens in convalescent Covid-19 patients and vaccinated subjects. Methodology: Cross-sectional study that has recruited 24 donors so far, with positive and/or negative SARS-CoV2 serology and who have or do not serological MMR signature. PBMC cultures were labeled using MitoTracker™ (Invitrogen), upon different MMR concentration. Herein, cell proliferation by FACS and S1, S2 and N-protein of SARS-CoV2 antibodies measured by ELISA. Results: B cells from SARS-CoV2 vaccinated and/or convalescent individuals for undergo proliferation when stimulated with 25 and 50 IU/mL of MMR. These cells produce antibodies of the IgG class against S2 and N- protein of SARS-CoV2. MMR (+) Covid19(-) control group showed proliferation with production of anti-SARS- CoV2 antibodies. Conclusion: MMR antigens induces B cells proliferation and antibodies that present cross- reactivity against SARS-CoV2 S2 and N-protein. | en_US |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Instituto. Salvador, BA, Brasil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Instituto. Salvador, BA, Brasil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Instituto. Salvador, BA, Brasil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Gonçalo Moniz Instituto. Salvador, BA, Brasil. | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | B cells | en_US |
| Subject | MMR | en_US |
| DeCS | SARS-CoV-2 | en_US |
| DeCS | Linfoma de Células B | en_US |
| DeCS | Vacina contra Sarampo-Caxumba-Rubéola | en_US |
