| Author | Frankenfeld, Julia | |
| Author | Miranda, Luisa H. M. | |
| Author | Carvalho, Beatriz W. | |
| Author | Reis, Érica G. | |
| Author | Riond, Barbara | |
| Author | Stirn, Martina | |
| Author | Bönzli, Eva | |
| Author | Suter, Vanessa | |
| Author | Meili, Theres | |
| Author | Pereira, Sandro A. | |
| Author | Conceição-Silva, Fátima | |
| Author | Hofmann-Lehmann, Regina | |
| Access date | 2024-07-23T23:26:57Z | |
| Available date | 2024-07-23T23:26:57Z | |
| Document date | 2018 | |
| Citation | FRANKENFELD, Julia et al. Acute Phase Proteins as Prognostic Markers and Presence of Coinfections in Cats with Sporotrichosis. In: INTERNATIONAL SOCIETY FOR COMPANION ANIMAL INFECTIOUS DISEASES SYMPOSIUM, 5., 2018, Portland. Anais... Portland: ISCAID, 2018. 2 p. | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/65126 | |
| Sponsorship | Swiss National Science Foundation (SNSF), Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) and PAEF-IOC-Fiocruz (IOC-008-FIO-15). Luisa Helena Monteiro de Miranda holds a research fellowship of Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). | en_US |
| Language | eng | en_US |
| Publisher | ISCAID | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Proteínas de fase aguda | en_US |
| Subject in Portuguese | Esporotricose felina | en_US |
| Title | Acute Phase Proteins as Prognostic Markers and Presence of Coinfections in Cats with Sporotrichosis | en_US |
| Type | Papers presented at events | en_US |
| Abstract | Background: Sporotrichosis is a severe, potentially lethal, fungal disease in cats. Treatment is not always successful and infected cats pose an infection risk to humans (zoonosis). Aims Defining prognostic markers for feline sporotrichosis and investigating coinfections in the urban area of Rio de Janeiro. Methods: Blood/serum samples from 14 naturally infected cats were collected at the time of diagnosis and during follow-up. Seven cats were treated with itraconazole only; seven cats received additionally potassium iodide. Haptoglobin, albumin and serum amyloid A (SAA) were measured by ELISA or on an automated analyzer. Antibodies against feline herpesvirus, calicivirus, parvovirus and coronavirus were tested by immunofluorescence assay. qPCR was used for the detection of feline Gammaherpesvirus, Bartonella henselae, Rickettsia spp., Anaplasma phagocytophilum, feline leukemia provirus, Cytauxzoon felis and feline hemoplasmas. Antibodies to feline immunodeficiency virus and feline leukemia virus antigen were tested by western blot and/or ELISA. Results: Clinical cure occurred in 10/14 cats. Curative success was independent of the drugs used. SAA but not albumin and haptoglobin levels were significantly higher in non-cured compared to cured cats at time of diagnosis. Two cured cats were FeLV-viremic, two were Mycoplasma haemofelis-positive and one was feline Gammaherpesvirus and Bartonella positive. Non-cured cats were not significantly more often coinfected or seropositive for the tested pathogens than cured cats. Discussion/Conclusions: SAA determined at the time of sporotrichosis diagnosis may be used as prognostic marker. The detection of high SAA may indicate the need for careful follow-up for early recognition of treatment failure. Disclosures: The project is funded by the Swiss National Science Foundation (SNSF), Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) and PAEF-IOC-Fiocruz (IOC-008-FIO-15). Luisa Helena Monteiro de Miranda holds a research fellowship of Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). | en_US |
| Affilliation | University of Zurich. Vetsuisse Facility. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Immunoparasitology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | University of Zurich. Vetsuisse Facility. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland. | en_US |
| Affilliation | University of Zurich. Vetsuisse Facility. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland. | en_US |
| Affilliation | University of Zurich. Vetsuisse Facility. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland. | en_US |
| Affilliation | University of Zurich. Vetsuisse Facility. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland. | en_US |
| Affilliation | University of Zurich. Vetsuisse Facility. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Immunoparasitology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | University of Zurich. Vetsuisse Facility. Clinical Laboratory and Center for Clinical Studies. Zurich, Switzerland. | en_US |
| Subject | Acute phase proteins | en_US |
| Subject | Feline sporotrichosis | en_US |
| Event date | 2018 | |
| Event Location | Portland, Oregon | en_US |
| Event title | 5th International Society for Companion Animal Infectious Diseases Symposium - 2018 ISCAID | en_US |
| Event type | simposium | en_US |
