| Author | Fajardo‑Martinez, Viviana | |
| Author | Ferreira, Fatima | |
| Author | Fuller, Trevon | |
| Author | Cambou, Mary Catherine | |
| Author | Kerin, Tara | |
| Author | Paiola, Sophia | |
| Author | Mok, Thalia | |
| Author | Rao, Rashmi | |
| Author | Mohole, Jyodi | |
| Author | Paravastu, Ramya | |
| Author | Zhang, Dajie | |
| Author | Marschik, Peter | |
| Author | Iyer, Sai | |
| Author | Kesavan, Kalpashri | |
| Author | Lopes, Maria da Conceição Borges | |
| Author | Britto, José Augusto A. | |
| Author | Moreira, Maria Elisabeth | |
| Author | Brasil, Patricia | |
| Author | Nielsen‑Saines, Karin | |
| Access date | 2024-07-23T23:44:50Z | |
| Available date | 2024-07-23T23:44:50Z | |
| Document date | 2024 | |
| Citation | FAJARDO-MARTINEZ, Viviana et al. Neurodevelopmental delay in children exposed to maternal SARS‑CoV‑2 in‑utero. Scientific Reports, v. 14, n. 1, p. 1-11, May 2024. | en_US |
| ISSN | 2045-2322 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/65133 | |
| Sponsorship | Te funding was provided by National Institutes of Health (Grant Nos. T32MH080634, AI140718, AI140718), Simons Foundation (Grant No. 866410) and W. M. Keck Foundation (Grant No. 9999). | en_US |
| Language | eng | en_US |
| Publisher | Nature Publishing Group | en_US |
| Rights | open access | en_US |
| Title | Neurodevelopmental delay in children exposed to maternal SARS‑CoV‑2 in‑utero | en_US |
| Type | Article | en_US |
| DOI | 10.1038/s41598-024-61918-2 | |
| Abstract | It is unclear if SARS CoV-2 infection during pregnancy is associated with adverse neurodevelopmental repercussions to infants. We assessed pediatric neurodevelopmental outcomes in children born to mothers with laboratory-confirmed SARS CoV-2 infection during pregnancy. Neurodevelopmental outcomes of in-utero exposed children were compared to that of pre-pandemic control children in Los Angeles (LA), CA, USA and Rio de Janeiro, Brazil. Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-III), the gold standard tool for evaluating neurodevelopment until 36 months of age and Ages and Stages Questionnaires (ASQ-3), a frequently used screening instrument for evaluating neurodevelopment in this same age group were the assessment tools used. Developmental delay (DD) was defined as having a score < - 2 SD below the norm (< 70) in at least one of three Bayley-III domains, (cognitive, motor or language) or a score below the cut-off (dark zone) in at least one of five ASQ-3 domains (communication, gross motor, fine motor, problem solving, personal-social). Exposed children were born between April 2020 and December 2022 while control children were born between January 2016 to December 2019. Neurodevelopmental testing was performed in 300 children total: 172 COVID-19 exposed children between 5-30 months of age and 128 control children between 6-38 months of age. Bayley-III results demonstrated that 12 of 128 exposed children (9.4%) had DD versus 2 of 128 controls (1.6%), p = 0.0007. Eight of 44 additional exposed children had DD on ASQ-3 testing. Fully, 20 of 172 exposed children (11.6%) and 2 of 128 control children (1.6%), p = 0.0006 had DD. In Rio, 12% of exposed children versus 2.6% of controls, p = 0.02 had DD. In LA, 5.7% of exposed children versus 0 controls, p = 0.12 had DD. Severe/critical maternal COVID-19 predicted below average neurodevelopment in the exposed cohort (OR 2.6, 95% CI 1.1-6.4). Children exposed to antenatal COVID-19 have a tenfold higher frequency of DD as compared to controls and should be offered neurodevelopmental follow-up. | en_US |
| Affilliation | David Geffen. UCLA School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | Universidade do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | UCLA Institute for the Environment and Sustainability. Los Angeles, CA, USA. | en_US |
| Affilliation | David Geffen. UCLA School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | David Geffen. UCLA School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | David Geffen. UCLA School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | David Geffen. UCLA School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | David Geffen. UCLA School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | David Geffen. UCLA School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | David Geffen. UCLA School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | Heidelberg University. Center for Psychosocial Medicine. Department of Child and Adolescent Psychiatry. Heidelberg, Germany / University Medical Center Göttingen and Leibniz ScienceCampus Primate Cognition. Child and Adolescent Psychiatry and Psychotherapy. Göttingen, Germany / Medical University of Graz. Division of Phoniatrics. Interdisciplinary Developmental Neuroscience. Graz, Austria. | en_US |
| Affilliation | Heidelberg University. Center for Psychosocial Medicine. Department of Child and Adolescent Psychiatry. Heidelberg, Germany / University Medical Center Göttingen and Leibniz ScienceCampus Primate Cognition. Child and Adolescent Psychiatry and Psychotherapy. Göttingen, Germany / Medical University of Graz. Division of Phoniatrics. Interdisciplinary Developmental Neuroscience. Graz, Austria. | en_US |
| Affilliation | David Geffen. UCLA School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | David Geffen. UCLA School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | David Geffen. UCLA School of Medicine. Los Angeles, CA, USA. | en_US |
| Subject | Neurodevelopmental repercussions | en_US |
| Subject | SARS CoV-2 | en_US |
| Subject | Infection during pregnancy | en_US |
| e-ISSN | 2045-2322 | |
