| Author | Cândido, Flávia Galvão | |
| Author | Silva, Alessandra da | |
| Author | Zanirate, Gilmara Alves | |
| Author | Oliveira, Nathallia Maria Cotta e | |
| Author | Hermsdorff, Helen Hermana Miranda | |
| Access date | 2024-07-26T13:19:09Z | |
| Available date | 2024-07-26T13:19:09Z | |
| Document date | 2024 | |
| Citation | CÂNDIDO, Flávia Galvão et al. Lymphocyte to high‑density lipoprotein cholesterol ratio is positively associated with pre‑diabetes, metabolic syndrome, and non‑traditional cardiometabolic risk markers: a cross‑sectional study at secondary health care. Inflammation, p. 1-13, 6 June 2024. | |
| ISSN | 0360-3997 | |
| URI | https://www.arca.fiocruz.br/handle/icict/65180 | |
| Description | Produção científica do Laboratório de Educação em Ambiente e Saúde. | pt_BR |
| Sponsorship | This paper is related to the project "Elaboration of guidelines and tools to obesity management in the Unified Health System: from Prevention to treatment", supported by the Agreement Letter between the Arthur Bernardes Foundation, Pan-American Health Organization, and Federal University of Viçosa (Funarbe/OPAS/UFV, process number SCON2021-00201). The CAPES Foundation has also supported this study (Code 001). | en_US |
| Sponsorship | Flávia Galvão Cândido (process number 151832/2022–6) is a National Council for Scientific and Technological Development postdoctoral fellowship. | |
| Sponsorship | Helen Hermana Miranda Hermsdorff is a National Council for Scientific and Technological Development fellowship in Research Productivity – 1D-level (process number 308772/2017–2). | |
| Sponsorship | The funders had no involvement in the paper. | |
| Language | eng | en_US |
| Publisher | Springer | |
| Rights | restricted access | |
| Title | Lymphocyte to high‑density lipoprotein cholesterol ratio is positively associated with pre‑diabetes, metabolic syndrome, and non‑traditional cardiometabolic risk markers: a cross‑sectional study at secondary health care | en_US |
| Type | Article | |
| DOI | 10.1007/s10753-024-02063-w | |
| Abstract | High scores of lymphocyte-to-high-density lipoprotein cholesterol ratio (lymphocyte-to-HDL-c) may be a new indicator of inflammation and metabolic syndrome. Here, we investigated the associations of the lymphocyte-to-HDL-c with traditional and non-traditional cardiometabolic risk markers in subjects at high cardiovascular risk. This study is a cross-sectional analysis with subjects assisted in a Secondary Health Care (n = 581, age = 63.06 ± 13.86 years; 52.3% women). Lymphocyte-to-HDL-c ratio were assessed by routine laboratory tests. Anthropometric and/or biochemical variables were used to calculate traditional (body mass index – BMI, and waist-to-height ratio – WHtR) and non-traditional (lipid accumulation product index—LAP, visceral adiposity index—VAI, deep-abdominal-adipose-tissue index—DAAT, atherogenic index of plasma—AIP, and waist-hypertriglyceridemic phenotype—HTGW) cardiometabolic risk markers. Furthermore, anthropometric measurement waist circumference (WC), blood pressure, metabolic syndrome (MS), and biochemical markers (lipid and glycemic profile) were considered traditional markers of cardiometabolic risk. Pearson's chi-square test, Poisson regression with robust variance, or multinomial logistic regression were performed (α = 0.05). Individuals with a high lymphocyte-HDL-c ratio (> 0.84, 3rd tertile) were associated with the HTGW phenotype, high VAI, high LAP, hypertriglyceridemia, high AIP, high very low-density lipoprotein-cholesterol (VLDL-c), pre-diabetes, and 3 and 4 MS components compared with individuals in the first tertile, independent of confounders. Our findings supported the lymphocyte-to-HDL-c ratio as a potential biomarker during the screening of subjects at high cardiovascular risk. | en_US |
| Affilliation | Universidade Federal de Viçosa. Centro de Ciências Biológicas e da Saúde. Departamento de Nutrição e Saúde. Viçosa, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal de Viçosa. Centro de Ciências Biológicas e da Saúde. Departamento de Nutrição e Saúde. Viçosa, MG, Brasil. | |
| Affilliation | Universidade Federal de Viçosa. Centro de Ciências Biológicas e da Saúde. Departamento de Nutrição e Saúde. Viçosa, MG, Brasil. | |
| Affilliation | Universidade Federal de Viçosa. Centro de Ciências Biológicas e da Saúde. Departamento de Nutrição e Saúde. Viçosa, MG, Brasil / Universidade Federal de Viçosa. Instituto de Políticas Públicas e Desenvolvimento Sustentável. Viçosa, MG, Brasil. | |
| Subject | Metabolic Syndrome | en_US |
| Subject | Insulin resistance | en_US |
| Subject | Central obesity | en_US |
| Subject | Visceral fat | en_US |
| Subject | Immunological mechanisms | en_US |
| Subject | Mediators | en_US |
| Subject | Index | en_US |
| e-ISSN | 1573-2576 | |
