| Author | Oliveira, Arão Belitardo de | |
| Author | Schytz, Henrik Winter | |
| Author | Peres, Mario Fernando Prieto | |
| Author | Mercante, Juliane Prieto Peres | |
| Author | Brunoni, André Russowsky | |
| Author | Wang, Yuan Pang | |
| Author | Molina, Maria del Carmen Bisi | |
| Author | Uchiyama, Lucas Koji | |
| Author | Lotufo, Paulo Andrade | |
| Author | Jensen, Rigmor Højland | |
| Author | Benseñor, Isabela Judith Martins | |
| Author | Griep, Rosane Härter | |
| Author | Goulart, Alessandra Carvalho | |
| Access date | 2024-07-26T14:42:19Z | |
| Available date | 2024-07-26T14:42:19Z | |
| Document date | 2024 | |
| Citation | OLIVEIRA, Arão Belitardo de et al. Does physical activity and inflammation mediate the job stress-headache relationship? A sequential mediation analysis in the ELSA-Brasil study. Brain, Behavior, and Immunity, v. 120, p. 187-198, Aug. 2024. | |
| ISSN | 0889-1591 | |
| URI | https://www.arca.fiocruz.br/handle/icict/65186 | |
| Description | Produção científica do Laboratório de Educação em Ambiente e Saúde. | pt_BR |
| Sponsorship | This work was supported by the Brazilian Ministry of Health (Science and Technology Department) and the Brazilian Ministry of Science and Technology (Financiadora de Estudos e Projetos - FINEP and CNPq National Research Council) (grants of baseline: 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ). | |
| Sponsorship | São Paulo Research Foundation - FAPESP (Thematic project number 2020/09468-9). | |
| Sponsorship | Post-doctoral fellowship number 2023/03011-5. | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| Title | Does physical activity and inflammation mediate the job stress-headache relationship? A sequential mediation analysis in the ELSA-Brasil study | en_US |
| Type | Article | |
| DOI | 10.1016/j.bbi.2024.06.002 | |
| Abstract | Background: Evidence indicates that physical activity reduces stress and promote a myriad of health-enhancing effects through anti-inflammatory mechanisms. However, it is unknown whether these mechanisms interfere in the association between psychosocial job stress and headache disorders. Objective: To test whether physical activity and its interplay with the systemic inflammation biomarkers high-sensitivity C-reactive protein (hs-CRP) and acute phase glycoproteins (GlycA) would mediate the associations between job stress and headache disorders. Methods: We cross-sectionally evaluated the baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) regarding job stress (higher demand and lower control and support subscales), migraine and tension-type headache (ICHD-2 criteria), self-reported leisure-time physical activity, and plasma hs-CRP and GlycA levels. Conditional process analyses with a sequential mediation approach were employed to compute path coefficients and 95 % confidence intervals (CI) around the indirect effects of physical activity and biomarkers on the job stress-headache relationship. Separate models were adjusted for sex, age, and depression and anxiety. Further adjustments added BMI smoking status, and socioeconomic factors. Results: In total, 7,644 people were included in the study. The 1-year prevalence of migraine and tension-type headache were 13.1 % and 49.4 %, respectively. In models adjusted for sex, age, anxiety, and depression, the association between job stress (lower job control) and migraine was mediated by physical activity [effect = −0.039 (95 %CI: −0.074, −0.010)] but not hs-CRP or GlycA. TTH was associated with higher job control and lower job demand, which was mediated by the inverse associations between physical activity and GlycA [Job Control: effect = 0.0005 (95 %CI: 0.0001, 0.0010); Job Demand: effect = 0.0003 (95 %CI: 0.0001, 0.0007]. Only the mediating effect of physical activity in the job stress-migraine link remained after further adjustments including socioeconomic factors, BMI, smoking, and the exclusion of major chronic diseases. Conclusion: In the ELSA-Brasil study, physical activity reversed the link between job stress and migraine independently of systemic inflammation, while the LTPA-mediated downregulation of GlycA was associated with lower job stress-related TTH. | en_US |
| Affilliation | Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | |
| Affilliation | University of Copenhagen. Rigshospitalet Glostrup Valdemar Hansens Vej. Department of Neurology. Danish Headache Center. Glostrup, Denmark. | |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto de Psiquiatria. São Paulo, SP, Brasil / Hospital Israelita Albert Einstein. Instituto do Cérebro. São Paulo, SP, Brasil. | |
| Affilliation | Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto de Psiquiatria. São Paulo, SP, Brasil / Hospital Israelita Albert Einstein. Instituto do Cérebro. São Paulo, SP, Brasil. | |
| Affilliation | Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto de Psiquiatria. São Paulo, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. | |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto de Psiquiatria. São Paulo, SP, Brasil. | |
| Affilliation | Universidade Federal de Ouro Preto. Ouro Preto, MG, Brasil. | |
| Affilliation | Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | |
| Affilliation | Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. | |
| Affilliation | University of Copenhagen. Rigshospitalet Glostrup Valdemar Hansens Vej. Department of Neurology. Danish Headache Center. Glostrup, Denmark. | |
| Affilliation | Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil / Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia. São Paulo, SP, Brasil. | |
| Subject | Physical Activity | en_US |
| Subject | Migraine | en_US |
| Subject | Tension-type Headache | en_US |
| Subject | C-reactive Protein | en_US |
| Subject | Acute Phase Glycoproteins | en_US |
| Subject | Occupational Health | en_US |
| Subject | Occupational Stress | en_US |
| e-ISSN | 1090-2139 | |
