| Author | Bally, Daniela Romero | |
| Author | Santos, Simone da Silva | |
| Author | Arregue, Diego Calafate | |
| Author | Mattos, Mariana Kelly de | |
| Author | Suárez Mutis, Martha Cecilia | |
| Access date | 2024-07-30T13:30:08Z | |
| Available date | 2024-07-30T13:30:08Z | |
| Document date | 2024 | |
| Citation | BALLY, Daniela Romero et al. High frequency of deletions in the pfhrp2 and pfhrp3 genes of plasmodium falciparum in the middle Rio Negro region of the brazilian Amazon. Tropical Medicine and Infectious Disease, v. 9, n. 7, p. 1-11, 2 July 2024. | |
| ISSN | 2414-6366 | |
| URI | https://www.arca.fiocruz.br/handle/icict/65208 | |
| Description | Produção científica do Laboratório de Doenças Parasitárias. | pt_BR |
| Sponsorship | This research was funded by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (Faperj), grant number E-26/210.433/2019. | |
| Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001. | |
| Sponsorship | Martha Cecilia Suárez Mutis was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq, grant number 314801/2021-9. | |
| Language | eng | en_US |
| Publisher | MDPI | |
| Rights | open access | |
| Title | High frequency of deletions in the pfhrp2 and pfhrp3 genes of plasmodium falciparum in the middle Rio Negro region of the brazilian Amazon | en_US |
| Type | Article | |
| DOI | 10.3390/tropicalmed9070149 | |
| Abstract | Several countries are reporting natural populations of P. falciparum with deletions in the pfhrp2/3 genes that can lead to false-negative results in rapid diagnostic tests. To investigate the prevalence of deletion in the pfhrp2/3 genes in the Rio Negro basin in the Brazilian Amazon and identify whether there is clinical differentiation between individuals infected by these parasites, clinical samples collected from 2003 to 2016 were analyzed from symptomatic and asymptomatic P. falciparum-infected individuals. The molecular deletion of pfhrp2 and pfhrp3 genes was evaluated using the protocols recommended by the WHO. From 82 samples used, 28 (34.2%) had a single deletion in pfhrp2, 19 (23.2%) had a single deletion in pfhrp3, 15 (18.3%) had a double deletion (pfhrp2/3), and 20 (24.4%) did not have a deletion in either gene. In total, 29.3% of individuals had an asymptomatic plasmodial infection and were 3.64 times more likely to have parasites with a double deletion (pfhrp2/3) than patients with clinical malaria (p = 0.02). The high prevalence of parasites with pfhrp2/3 deletions shows the need to implement a surveillance program in this area. Deletions in parasites may be associated with the clinical pattern of the disease in this area. More studies must be carried out to elucidate these findings. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Medicina Tropical. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | |
| Subject | Malaria | en_US |
| Subject | P. falciparum | en_US |
| Subject | Brazilian Amazon | en_US |
| Subject | pfhrp2/3 deletions | en_US |
| Subject | Rapid diagnostic tests | en_US |
| Subject | Elimination | en_US |
| e-ISSN | 2414-6366 | |
