| Author | Arriaga, María B. | |
| Author | Amorim, Gustavo | |
| Author | Figueiredo, Marina C. | |
| Author | Staats, Cody | |
| Author | Kritski, Afrânio L. | |
| Author | Santos, Marcelo Cordeiro | |
| Author | Rolla, Valeria C. | |
| Author | Andrade, Bruno B. | |
| Author | Sterling, Timothy R. | |
| Access date | 2024-08-02T14:05:57Z | |
| Available date | 2024-08-02T14:05:57Z | |
| Document date | 2024 | |
| Citation | ARRIAGA, María B. et al. Effect of smoking on longitudinal interferon γ release assay results among close contacts of people with pulmonary tuberculosis. The Journal of Infectious Diseases, p. 1-6, 2024. | en_US |
| ISSN | 1537-6613 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/65235 | |
| Sponsorship | National Institutes of Health (HIN).
Programa de Pesquisa Intramuros da FIOCRUZ.
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Ministério da Saúde, Brasil. | en_US |
| Language | eng | en_US |
| Publisher | Oxford University Press | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Ensaios de liberação de interferon γ | en_US |
| Subject in Portuguese | IGRA | en_US |
| Subject in Portuguese | Tuberculose | en_US |
| Subject in Portuguese | Contatos próximos | en_US |
| Subject in Portuguese | Fumar | en_US |
| Title | Effect of smoking on longitudinal interferon γ release assay results among close contacts of people with pulmonary tuberculosis | en_US |
| Type | Article | en_US |
| DOI | 10.1093/infdis/jiae285 | |
| Abstract | Diagnosis of Mycobacterium tuberculosis infection in close contacts is critical for tuberculosis control. Smoking is a risk factor for M. tuberculosis infection and tuberculosis disease but its effect on longitudinal interferon γ release assay (IGRA) results remains unknown. We conducted a multisite prospective study in Brazil between 2015 and 2019, among close contacts of adults with culture-confirmed pulmonary tuberculosis. IGRA was performed at baseline, at month 6 if results were negative at baseline, and at months 24–30 after enrollment. IGRA results were categorized as IGRA positive (maintained from baseline to the last visit), IGRA conversion (from negative to positive at any time), IGRA reversion (from positive to negative at any time), and IGRA negative (maintained from baseline to the last visit). Associations between IGRA results and smoking status at baseline (current/former vs never) in contacts were evaluated using propensity score-adjusted logistic regression models. Estimated propensity score was used as a covariate in models, which regressed the outcome (IGRA positive, IGRA conversion, IGRA reversion) on smoking status. Of 430 close contacts, 89 (21%) were IGRA positive, 30 (7%) were converters, 30 (7%) were reverters and 22 were indeterminate. Smoking frequency was 26 (29%) among IGRA-positive contacts, 7 (23%) in converters, and 3 (10%) in reverters. Smoking in contacts was associated with lower odds of IGRA reversion (adjusted odds ratio, 0.16 [95% confidence interval, .03–.70]). We did not detect associations between smoking and IGRA positive or IGRA conversion. Our findings highlight the importance of smoking on longitudinal IGRA results. This has implications for clinical care and clinical trials in which IGRA status is monitored or used as an outcome. | en_US |
| Affilliation | Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine. Nashville, Tennessee, USA. | en_US |
| Affilliation | Department of Biostatistics. Vanderbilt University Medical Center. Nashville, Tennessee, USA. | en_US |
| Affilliation | Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine. Nashville, Tennessee, USA. | en_US |
| Affilliation | Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine. Nashville, Tennessee, USA. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Medicina Tropical Doutor Heitor Vieira Dourado. Faculdade de Medicina. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil / Universidade Nilton Lins. Faculdade de Medicina. Manaus, AM, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Curso de Medicina. Salvador, BA, Brasil / Instituto de Pesquisa Clínica e Translacional, Faculdade de Tecnologia e Ciências, Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil /Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil. | en_US |
| Affilliation | Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine. Nashville, Tennessee, USA / Universidade Salvador. Curso de Medicina. Salvador, BA, Brasil. | en_US |
| Subject | Interferon γ release assays | en_US |
| Subject | IGRA | en_US |
| Subject | Tuberculosis | en_US |
| Subject | Close contacts | en_US |
| Subject | Smoking | en_US |
| DeCS | Interferons | en_US |
| DeCS | Tuberculose | en_US |
| DeCS | Fumar | en_US |
| Embargo date | 2025 | |
