| Author | Miguel, Isaac | |
| Author | Feliz, Edwin P. | |
| Author | Agramonte, Robinson | |
| Author | Martinez, Pedro V. | |
| Author | Vergara, Carlos | |
| Author | Imbert, Yvonne | |
| Author | Cruz, Lucia de la | |
| Author | Castro, Nurys de | |
| Author | Cedano, Odalis | |
| Author | Paz, Yamilka de la | |
| Author | Fonseca, Vagner de Souza | |
| Author | Santiago, Gilberto A. | |
| Author | Muñoz‑Jordán, Jorge L. | |
| Author | Peguero, Armando | |
| Author | Paulino‑Ramírez, Robert | |
| Author | Grubaugh, Nathan D. | |
| Author | Filippis, Ana Maria Bispo de | |
| Author | Alcantara, Luiz Carlos Júnior | |
| Author | Mendez Rico, Jairo | |
| Author | Lourenço, José | |
| Author | Franco, Leticia | |
| Author | Giovanetti, Marta | |
| Access date | 2024-08-08T13:18:11Z | |
| Available date | 2024-08-08T13:18:11Z | |
| Document date | 2024 | |
| Citation | MIGUEL, Isaac et al. North-south pathways, emerging variants, and high climate suitability characterize the recent spread of dengue virus serotypes 2 and 3 in the Dominican Republic. BMC Infectious Diseases, v. 24, n. 751, p. 1-8, 29 July 2024. | |
| ISSN | 1471-2334 | |
| URI | https://www.arca.fiocruz.br/handle/icict/65291 | |
| Description | Produção científica do Laboratório de Arbovírus e Vírus Hemorrágicos. | pt_BR |
| Sponsorship | This study received support from various organizations and institutions. | |
| Sponsorship | Specifically, funding was provided by the Pan American Health Organization (PAHO), the United States Agency for International Development (USAID), and the Dominican Republic Public Health Ministry under the supervision of Isaac Miguel. | |
| Sponsorship | Furthermore, the National Institutes of Health (NIH) in the United States contributed through grant U01 AI151698 for the United World Arbovirus Research Network (UWARN), under the supervision of Luiz Carlos Júnior Alcantara. | |
| Sponsorship | Moreover, support was also received from the CRP-ICGEB RESEARCH GRANT 2020 Project CRP/BRA20-03, Contract CRP/20/03, overseen by Marta Giovanetti. | |
| Sponsorship | Marta Giovanetti's funding is provided by PON "Ricerca e Innovazione" 2014–2020. | |
| Language | eng | en_US |
| Publisher | BMC | |
| Previous version | https://www.arca.fiocruz.br/handle/icict/64671 | |
| Rights | open access | |
| Title | North-south pathways, emerging variants, and high climate suitability characterize the recent spread of dengue virus serotypes 2 and 3 in the Dominican Republic | en_US |
| Type | Article | |
| DOI | 10.1186/s12879-024-09658-6 | |
| Abstract | Background: Dengue fever remains a significant public health challenge in tropical and subtropical regions, with its transmission dynamics being influenced by both environmental factors and human mobility. The Dominican Republic, a biodiversity hotspot in the Caribbean, has experienced recurrent dengue outbreaks, yet detailed understanding of the virus's transmission pathways and the impact of climatic factors remains limited. This study aims to elucidate the recent transmission dynamics of the dengue virus (DENV) in the Dominican Republic, utilizing a combination of genomic sequencing and epidemiological data analysis, alongside an examination of historical climate patterns. Methods: We conducted a comprehensive study involving the genomic sequencing of DENV samples collected from patients across different regions of the Dominican Republic over a two-year period. Phylogenetic analyses were performed to identify the circulation of DENV lineages and to trace transmission pathways. Epidemiological data were integrated to analyze trends in dengue incidence and distribution. Additionally, we integrated historical climate data spanning several decades to assess trends in temperature and their potential impact on DENV transmission potential. Results: Our results highlight a previously unknown north–south transmission pathway within the country, with the co-circulation of multiple virus lineages. Additionally, we examine the historical climate data, revealing long-term trends towards higher theoretical potential for dengue transmission due to rising temperatures. Conclusion: This multidisciplinary study reveals intricate patterns of dengue virus transmission in the Dominican Republic, characterized by the co-circulation of multiple DENV lineages and a novel transmission pathway. The observed correlation between rising temperatures and increased dengue transmission potential emphasizes the need for integrated climate-informed strategies in dengue control efforts. Our findings offer critical insights for public health authorities in the Dominican Republic and similar settings, guiding resource allocation and the development of preparedness strategies to mitigate the impacts of climate change on dengue transmission. | en_US |
| Affilliation | Laboratorio Nacional de Referencia en Salud Pública Dr. Defilló. Santo Domingo, Dominican Republic. | |
| Affilliation | Laboratorio Nacional de Referencia en Salud Pública Dr. Defilló. Santo Domingo, Dominican Republic. | |
| Affilliation | Laboratorio Nacional de Referencia en Salud Pública Dr. Defilló. Santo Domingo, Dominican Republic. | |
| Affilliation | Laboratorio Nacional de Referencia en Salud Pública Dr. Defilló. Santo Domingo, Dominican Republic. | |
| Affilliation | Laboratorio Nacional de Referencia en Salud Pública Dr. Defilló. Santo Domingo, Dominican Republic. | |
| Affilliation | Laboratorio Nacional de Referencia en Salud Pública Dr. Defilló. Santo Domingo, Dominican Republic. | |
| Affilliation | Laboratorio Nacional de Referencia en Salud Pública Dr. Defilló. Santo Domingo, Dominican Republic. | |
| Affilliation | Laboratorio Nacional de Referencia en Salud Pública Dr. Defilló. Santo Domingo, Dominican Republic. | |
| Affilliation | Laboratorio Nacional de Referencia en Salud Pública Dr. Defilló. Santo Domingo, Dominican Republic. | |
| Affilliation | Laboratorio Nacional de Referencia en Salud Pública Dr. Defilló. Santo Domingo, Dominican Republic. | |
| Affilliation | Universidade do Estado da Bahia. Campus Salvador. Departamento de Ciências Exatas e da Terra. Salvador, BA, Brasil. | |
| Affilliation | Centers for Disease Control and Prevention. Division of Vector-Borne Diseases. San Juan, Puerto Rico. | |
| Affilliation | Centers for Disease Control and Prevention. Division of Vector-Borne Diseases. San Juan, Puerto Rico. | |
| Affilliation | Universidad Iberoamericana. Instituto de Medicina Tropical & Salud Global. Santo Domingo, Dominican Republic. | |
| Affilliation | Universidad Iberoamericana. Instituto de Medicina Tropical & Salud Global. Santo Domingo, Dominican Republic. | |
| Affilliation | Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA / Yale University. Yale Institute for Global Health. New Haven, CT, USA / Yale University. Department of Ecology and Evolutionary Biology. New Haven, CT, USA / Yale School of Public Health. Public Health Modeling Unit. New Haven, CT, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Arbovírus e Vírus Hemorrágicos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Affilliation | World Health Organization. Pan American Health Organization. Health Emergencies Department. Infectious Hazards Management. Washington, DC, USA. | |
| Affilliation | Universidade Católica Portuguesa. Faculdade de Medicina. Biomedical Research Center. Lisboa, Portugal. | |
| Affilliation | World Health Organization. Pan American Health Organization. Health Emergencies Department. Infectious Hazards Management. Washington, DC, USA. | |
| Affilliation | Università Campus Bio-Medico diRoma. Department of Sciences and Technologies for Sustainable Development and One Health. Rome, Italy / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Subject | Dengue virus | en_US |
| Subject | Genomic epidemiology | en_US |
| Subject | Dominican Republic | en_US |
| Subject | Caribbean | en_US |
| e-ISSN | 1471-2334 | |
