| Author | Halai, Umme-Aiman | |
| Author | Nielsen-Saines, Karin | |
| Author | Moreira, Maria Elisabeth Lopes | |
| Author | Sequeira, Patricia Carvalho de | |
| Author | Pereira Junior, Jose Paulo | |
| Author | Zin, Andrea de Araujo | |
| Author | Cherry, James | |
| Author | Gabaglia, Claudia Raja | |
| Author | Gaw, Stephanie L. | |
| Author | Adachi, Kristina | |
| Author | Tsui, Irena | |
| Author | Pilotto, Jose Henrique | |
| Author | Nogueira, Rita Ribeiro | |
| Author | Filippis, Ana Maria Bispo de | |
| Author | Brasil, Patricia | |
| Access date | 2024-09-06T02:50:45Z | |
| Available date | 2024-09-06T02:50:45Z | |
| Document date | 2017 | |
| Citation | HALAI, Umme-Aiman et al. Maternal Zika Virus Disease Severity, Virus Load, Prior Dengue Antibodies, and Their Relationship to Birth Outcomes. Clinical Infectious Diseases, v. 65, n. 6, p. 877-883, Sep. 2017. | en_US |
| ISSN | 1058-4838 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/65784 | |
| Sponsorship | This work was supported by the Departamento de Ciência e Tecnologia (DECIT) do Ministério da Saúde do Brasil and grants from Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES/ 88887.116627/2016-01); the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (AI28697 and 1R21AI129534-01) and the Thrasher Research Fund (20164370). | en_US |
| Language | eng | en_US |
| Publisher | Oxford | en_US |
| Previous version | https://www.arca.fiocruz.br/handle/icict/19076 | en_US |
| Rights | open access | |
| Title | Maternal Zika Virus Disease Severity, Virus Load, Prior Dengue Antibodies, and Their Relationship to Birth Outcomes | en_US |
| Type | Article | |
| DOI | 10.1093/cid/cix472 | |
| Abstract | Background: Congenital Zika virus (ZIKV) syndrome is a newly identified condition resulting from infection during pregnancy. We analyzed outcome data from a mother-infant cohort in Rio de Janeiro in order to assess whether clinical severity of maternal ZIKV infection was associated with maternal virus load, prior dengue antibodies, or abnormal pregnancy/infant outcomes. Methods: A clinical severity assessment tool was developed based on duration of fever, severity of rash, multisystem involvement, and duration of symptoms during ZIKV infection. ZIKV-RNA load was quantified by polymerase chain reaction (PCR) cycles in blood/ urine. Dengue immunoglobulin G (IgG) antibodies were measured at baseline. Adverse outcomes were defined as fetal loss or a live infant with grossly abnormal clinical or brain imaging findings. Regression models were used to study potential associations. Results: 131 ZIKV-PCR positive pregnant women were scored for clinical disease severity, 6 (4.6%) had mild disease, 98 (74.8%) had moderate disease, and 27 (20.6%) severe manifestations of ZIKV infection. There were 58 (46.4%) abnormal outcomes with 9 fetal losses (7.2%) in 125 pregnancies. No associations were found between: disease severity and abnormal outcomes (P = .961; odds ratio [OR]: 1.00; 95% confidence interval [CI]: 0.796-1.270); disease severity and viral load (P = .994); viral load and adverse outcomes (P = .667; OR: 1.02; 95% CI: 0.922-1.135); or existence of prior dengue antibodies (88% subjects) with severity score, ZIKV-RNA load or adverse outcomes (P = .667; OR: 0.78; 95% CI: 0.255-2.397). Conclusions: Congenital ZIKV syndrome does not appear to be associated with maternal disease severity, ZIKV-RNA load at time of infection or existence of prior dengue antibodies. | en_US |
| Affilliation | University of California. David Geffen School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | University of California. David Geffen School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de FlavivÍrus. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | University of California. David Geffen School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | Biomedical Research Institute of Southern CA. Oceanside, CA, USA. | en_US |
| Affilliation | University of California. School of Medicine. San Francisco, CA, USA. | en_US |
| Affilliation | University of California. David Geffen School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | University of California. David Geffen School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | University of California. David Geffen School of Medicine. Los Angeles, CA, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Zika | en_US |
| Subject | Dengue | en_US |
| Subject | ZIKV | en_US |
| Subject | Pregnancy | en_US |
| Subject | Congenital | en_US |
| DeCS | Zika virus | en_US |
| DeCS | Dengue | en_US |
| e-ISSN | 1537-6591 | |
