| Author | Avanzi, Charlotte | |
| Author | Maia, Raquel Cristina | |
| Author | Benjak, Andrej | |
| Author | Nery, José Augusto da Costa | |
| Author | Sales, Anna Maria | |
| Author | Machado, Alice de Miranda | |
| Author | Duppre, Nádia Cristina | |
| Author | Fontes, Amanda Nogueira Brum | |
| Author | Silva, Tatiana Pereira da | |
| Author | Pinheiro, Roberta Olmo | |
| Author | Manta, Fernanda Saloum de Neves | |
| Author | Moreira, Suelen Justo Maria | |
| Author | Busso, Philippe | |
| Author | Sarno, Euzenir Nunes | |
| Author | Suffys, Philip Noel | |
| Author | Cole, Stewart Thomas | |
| Author | Moraes, Milton Ozório | |
| Access date | 2024-09-06T16:56:58Z | |
| Available date | 2024-09-06T16:56:58Z | |
| Document date | 2020 | |
| Citation | AVANZI, Charlotte et al. Emergence of mycobacterium leprae rifampin resistance evaluated by whole-genome sequencing after 48 years of irregular treatment. Antimicrobial Agents and Chemotherapy, v. 15, n. 5, p. 1-5, 23 June 2020. | |
| ISSN | 0066-4804 | |
| URI | https://www.arca.fiocruz.br/handle/icict/65793 | |
| Description | Produção científica do Laboratório de Biologia Molecular Aplicada a Micobactérias. | pt_BR |
| Description | Produção científica do Laboratório de Hanseníase. | pt_BR |
| Sponsorship | This work was supported by the Fondation Raoul Follereau (Stewart Thomas Cole). | |
| Sponsorship | Swiss National Science Foundation grant IZRJZ3_164174 (Stewart Thomas Cole). | |
| Sponsorship | Heiser Program of the New York Community Trust for Research in Leprosy grant numbers P16-000976 (Stewart Thomas Cole) and P18-00250 (Milton Ozório Moraes, Charlotte Avanzi). | |
| Sponsorship | Charlotte Avanzi is also supported by the Association de Chimiothérapie Anti-Infectieuse of the Société Française de Microbiologie, the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant no. 845479, and a nonstipendiary European Molecular Biology Organization (EMBO) long-term fellowship (ALTF 1086-2018). | |
| Language | eng | en_US |
| Publisher | American Society for Microbiology | |
| Previous version | https://www.arca.fiocruz.br/handle/icict/45088 | |
| Rights | open access | |
| Title | Emergence of mycobacterium leprae rifampin resistance evaluated by whole-genome sequencing after 48 years of irregular treatment | en_US |
| Type | Article | |
| DOI | 10.1128/aac.00330-20 | |
| Abstract | A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation in rpoC was also detected. Clinical improvement was achieved using an alternative therapy. | en_US |
| Affilliation | École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | École Polytechnique Fédérale de Lausanne. Global Health Institute. Lausanne, Switzerland / Institut Pasteur. Paris, France. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Subject | Leprosy | en_US |
| Subject | Mycobacterium leprae | en_US |
| Subject | Rifampin | en_US |
| Subject | Whole-genome sequencing | en_US |
| Subject | Resistance | en_US |
| Subject | Treatment | en_US |
| Subject | Relapse emergence | en_US |
| e-ISSN | 1098-6596 | |
