| Author | de La Roque, Debora Glenda Lima | |
| Author | Santos, Elaine Vieira | |
| Author | Policastro, Lucca Rocha | |
| Author | Costa, Péricles Natan Mendes da | |
| Author | Evaristo, Mariane | |
| Author | Yamamoto, Aparecida Yulie | |
| Author | Giomo, Denise Bergamaschi | |
| Author | Torres, Paula Marilia Afonso | |
| Author | Gentil, Danielle Cristina Dacanal | |
| Author | Minto, Elaine Cristina Manini | |
| Author | Slavov, Svetoslav Nanev | |
| Author | Fonseca, Vagner | |
| Author | Barros, Claudia Renata Dos Santos | |
| Author | Martins, Antonio Jorge | |
| Author | Calado, Rodrigo Tocantins | |
| Author | Passos, Luzia Márcia Romanholi | |
| Author | Elias, Maria Carolina | |
| Author | Sampaio, Sandra Coccuzzo | |
| Author | Giovanetti, Marta | |
| Author | Covas, Dimas Tadeu | |
| Author | Alcântara, Luiz Carlos Júnior | |
| Author | Kashima, Simone | |
| Access date | 2024-09-16T18:19:57Z | |
| Available date | 2024-09-16T18:19:57Z | |
| Document date | 2024 | |
| Citation | DE LA ROQUE, Debora Glenda Lima et al. Exploring the Chikungunya virus landscape in a dengue-endemic Brazilian area. Journal of Infection and Public Health, v. 17, n. 7, p. 102442, 2024. doi.org/10.1016/j.jiph.2024.04.026. | en_US |
| ISSN | 1876-0341 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/65900 | |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | open access | en_US |
| Title | Exploring the Chikungunya virus landscape in a dengue-endemic Brazilian area. | en_US |
| Type | Article | en_US |
| Abstract | We aimed to describe the landscape, including molecular, epidemiological, and clinical aspects of CHIKV infections in the Ribeirao Preto region, an area endemic to dengue. We randomly screened 3744 plasma samples that had undergone DENV diagnosis to evaluate CHIKV-RNA using an in-house RT-PCR assay. Positive samples were followed clinically, and RNA samples were submitted to whole genome sequencing. Seventeen cases (0.5 %) were positive for CHIKV-RNA despite being negative for DENV-RNA. Notably, half of the patients experienced prolonged arthralgia lasting more than 90 days. Compared with the healthy control group, leukopenia and thrombocytopenia were observed in all CHIKV-positive individuals with statistically significant P values (P < 0.0001 and P = 0.0003, respectively). The genomic analysis revealed that the CHIKV strains being studied are classified within the East-Central-South-African (ECSA) genotype. This analysis identified new mutations, E1: K211E and E2: V264A, while the previously known mutation E1: A226V was not detected among these strains. This study highlights the need for epidemiological surveillance and preparedness for potential CHIKV epidemics in Brazil, particularly where other arboviruses co-circulate. | en_US |
| Affilliation | Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil/Medical School of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Butantan Institute. São Paulo, SP, Brazil. | en_US |
| Affilliation | Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil/Medical School of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Medical School of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Prefeitura de Ribeirão Preto. Divisão de Vigilância Epidemiológica/Departamento de Vigilância em Saúde. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Divisão de Vigilância Epidemiológica/Departamento de Vigilância em Saúde. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Divisão de Vigilância Epidemiológica/Departamento de Vigilância em Saúde. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Secretaria da Saúde de Ribeirão Preto. Serviços de Exames Laboratoriais. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Butantan Institute. São Paulo, SP, Brazil. | en_US |
| Affilliation | Pan-American Health Organization. World Health Organization. New York, NY, United States American. | en_US |
| Affilliation | Butantan Institute. São Paulo, SP, Brazil. | en_US |
| Affilliation | Butantan Institute. São Paulo, SP, Brazil. | en_US |
| Affilliation | Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil/ Medical School of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Divisão de Vigilância Epidemiológica/Departamento de Vigilância em Saúde. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Butantan Institute. São Paulo, SP, Brazil. | en_US |
| Affilliation | Butantan Institute. São Paulo, SP, Brazil. | en_US |
| Affilliation | Sciences and Technologies for Sustainable Development and One Health, University of Campus Bio-Medico, Rome, Italy; Instituto Rene Rachou, Fundação Oswaldo Cruz, Minas Gerais, Brazil; Climate Amplified Diseases and Epidemics (CLIMADE), Brazil. | en_US |
| Affilliation | Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brazil/ Medical School of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Minas Gerais, Brazil; Climate Amplified Diseases and Epidemics.Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Blood Center of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil; Medical School of Ribeirão Preto, Ribeirão Preto, University of São Paulo, São Paulo, Brazil. | en_US |
| Subject | Arbovirus | en_US |
| Subject | Chikungunya virus | en_US |
| Subject | Molecular epidemiology | en_US |
| Subject | Phylogeny | en_US |
