| Author | Vieira, Carolina David | |
| Author | Carpinter, Bárbara Albuquerque | |
| Author | Bellei, Jéssica Correia Bezerra | |
| Author | Machado, Letícia Ferreira | |
| Author | Raimundo, Felipe Oliveira | |
| Author | Rodolphi, Cinthia Magalhães | |
| Author | Renhe, Daniela Chaves | |
| Author | Guedes, Isabella Rodrigues Nogueira | |
| Author | Gonçalves, Fernanda Mikaela Moreira | |
| Author | Pereira, Ludmila Ponce Monken Custódio | |
| Author | Ferreira, Marcos Vinicius Rangel | |
| Author | Nascimento, Haroldo Lobo dos Santos | |
| Author | Silva Neto, Adolfo Firmino da | |
| Author | Gomes, Flávia Lima Ribeiro | |
| Author | Rocha, Vinícius Novaes | |
| Author | Castro, Juciane Maria de Andrade | |
| Author | Scopel, Kézia Katiani Gorza | |
| Access date | 2024-09-24T13:55:43Z | |
| Available date | 2024-09-24T13:55:43Z | |
| Document date | 2024 | |
| Citation | VIEIRA, Carolina David et al. Lung damage induced by plasmodium berghei ANKA in murine model of malarial infection is mitigated by dietary supplementation with DHA-rich omega-3. ACS Infectious Diseases, p. 1-11, 20 Sept. 2024. | |
| ISSN | 2373-8227 | |
| URI | https://www.arca.fiocruz.br/handle/icict/66065 | |
| Description | Produção científica do Laboratório de Pesquisa em Malária. | pt_BR |
| Sponsorship | This research was funded by the Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG-Rede Mineira #00313-16 and APQ-1365-22), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 310272/2022-0), and Programa de Pós-Graduação em Ciências Biológicas of the Universidade Federal de Juiz de Fora. Carolina David Vieira and Barbara Albuquerque Carpinter received FAPEMIG fellowships. | |
| Language | eng | en_US |
| Publisher | American Chemical Society | |
| Rights | open access | |
| Title | Lung damage induced by plasmodium berghei ANKA in murine model of malarial infection is mitigated by dietary supplementation with DHA-rich omega-3 | en_US |
| Type | Article | |
| DOI | 10.1021/acsinfecdis.4c00482 | |
| Abstract | Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe complications that can occur in infections caused by any Plasmodium species. Due to the high lethality rate and the lack of specific treatment for ALI/ARDS, studies aimed at understanding and searching for treatment strategies for such complications have been fundamental. Here, we investigated the protective role of dietary supplementation with DHA-rich fish oil against lung damage induced by Plasmodium berghei ANKA in a murine model. Our results demonstrated that alveolar vascular damage, lung edema, and histopathological alterations were significantly reduced in mice that received dietary supplementation compared to those that did not receive the supplementation. Furthermore, a significant reduction in the number of CD8+ T lymphocytes, in addition to reduced infiltration of inflammatory cells in the bronchoalveolar lavage fluid was also observed. High levels of IL-10, but not of TNF-α and IFN-γ, were also observed in infected mice that received the supplementation, along with a reduction in local oxidative stress. Together, the data suggest that dietary supplementation with DHA-rich fish oil in malarial endemic areas may help reduce lung damage resulting from the infection, thus preventing worsening of the condition. | en_US |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Veterinary Medicine. Research Centre of Pathology and Veterinary Histology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Veterinary Medicine. Research Centre of Pathology and Veterinary Histology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Veterinary Medicine. Research Centre of Pathology and Veterinary Histology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Affilliation | Federal University of Juiz de Fora. Department of Parasitology, Microbiology and Immunology. Post-Graduate Program in Biological Science. Research Centre of Parasitology. Juiz de Fora, MG, Brasil. | |
| Subject | Malaria | en_US |
| Subject | Severe malaria | en_US |
| Subject | ARDS | en_US |
| Subject | Lung injury | en_US |
| Subject | Omega-3 PUFAs | en_US |
| Subject | DHA | en_US |
| e-ISSN | 2373-8227 | |
| xmlui.metadata.dc.subject.ods | 02 Fome zero e agricultura sustentável | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
