| Author | Viana, Paula Gonçalves | |
| Author | Gremião, Isabella Dib Ferreira | |
| Author | Antonio, Isabela Maria da Silva | |
| Author | Figueiredo, Anna Barreto Fernandes | |
| Author | Correa, Maria Lopes | |
| Author | Boechat, Jéssica Sepulveda | |
| Author | Machado, Ana Caroline de Sá | |
| Author | Oliveira, Raquel Vasconcelos Carvalhaes de | |
| Author | Oliveira, Manoel Marques Evangelista | |
| Author | Almeida-Paes, Rodrigo | |
| Author | Pereira-Oliveira, Gabriela Reis | |
| Author | Pereira, Sandro Antonio | |
| Access date | 2024-09-27T01:49:51Z | |
| Available date | 2024-09-27T01:49:51Z | |
| Document date | 2024 | |
| Citation | VIANA, Paula Gonçalves et al. Is terbinafine an effective treatment for feline sporotrichosis? The Veterinary Record, v. 195, n. 4, p. 1-5, Aug. 2024. | en_US |
| ISSN | 0042-4900 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/66147 | |
| Sponsorship | Jovem Cientista do Nosso Estado 2019 FAPERJ, Grant/Award Number: E-26/202.737/2019; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Grant/Award Numbers:
312238/202-7-SAP, 307007/2022-7-MMEO; Bolsista Nota 10 FAPERJ, Grant/Award Numbers: E-26/201.202.180/2018, E-26/201.715/2021; Jovem Cientista do Nosso Estado 2021−2024 FAPERJ,
Grant/Award Number: E-26/201.433/2021. | en_US |
| Language | eng | en_US |
| Publisher | British Veterinary Medicine | en_US |
| Rights | restricted access | |
| Title | Is terbinafine aneffective treatment for feline sporotrichosis? | en_US |
| Type | Article | |
| DOI | 10.1002/vetr.4435 | |
| Abstract | Background: Terbinafine has been successfully used in the treatment of human sporotrichosis; however, its effectiveness in the treatment of feline sporotrichosis is unknown. Therefore, this study aimed to describe the use of terbinafine in the treatment of feline sporotrichosis. Methods: A cohort study was conducted in cats with sporotrichosis to assess the effectiveness and safety of terbinafine (30‒60 mg/kg/day). Clinical examination and analysis of laboratory parameters were performed monthly until clinical signs resolved or terbinafine treatment was discontinued. Results: Of the 54 cats with sporotrichosis included in the study, 19 were lost during follow-up and five were withdrawn from the study due to switching to treatment with another prescription drug. Of the remaining 30 cats, 10 achieved clinical cure, with a median treatment time of 18.5 weeks. Treatment failed in 18 cases, and two cats died. Twenty-two cats had adverse reactions to terbinafine treatment, and 10 cats showed elevation of serum transaminases. Limitation: Loss during follow-up was high, which makes it difficult to draw accurate conclusions regarding clinical outcomes. Conclusion: The low rate of clinical cure observed suggests that terbinafine does not represent an effective treatment option for cases of feline sporotrichosis. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Epidemiology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Taxonomy, Biochemical and Bioprospecting of Fungi. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Mycology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil. | en_US |
| Subject | Cats | en_US |
| Subject | Sporothrix | en_US |
| Subject | Terbinafine | en_US |
| e-ISSN | 2042-7670 | |
| Embargo date | 2030-12-31 | |
