| Author | Coelho, Karoline Brito Caetano Andrade | |
| Author | Wosniaki, Denise Kusma | |
| Author | Marin, Anelis Maria | |
| Author | Fabris, Laura | |
| Author | Reis, Rodolfo Borges | |
| Author | Aoki, Mateus Nóbrega | |
| Author | Zanette, Dalila Lucíola | |
| Access date | 2024-10-04T16:37:55Z | |
| Available date | 2024-10-04T16:37:55Z | |
| Document date | 2024 | |
| Citation | COELHO, Karoline Brito Caetano Andrade et al. Urinary mRNA-based biomarkers for non-muscle-invasive bladder cancer: a mini-review. Frontiers in Oncology, v. 14, p. 1-8, Aug. 2024. | en_US |
| ISSN | 2234-943X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/66313 | |
| Sponsorship | CAPES | en_US |
| Language | eng | en_US |
| Publisher | Frontiers Media SA | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Biomarcadores urinários | en_US |
| Subject in Portuguese | Baseado em mRNA | en_US |
| Subject in Portuguese | Monitoramento | en_US |
| Subject in Portuguese | Neoplasias não Músculo Invasivas da Bexiga | en_US |
| Subject in Portuguese | Neoplasias Músculo Invasivas da Bexiga | en_US |
| Title | Urinary mRNA-based biomarkers for non-muscle-invasive bladder cancer: a mini-review | en_US |
| Type | Article | en_US |
| DOI | 10.3389/fonc.2024.1441883 | |
| Abstract | Bladder cancer (BC) is the second most common type of cancer of the urinary system. Approximately 75% of the cases are non-muscle invasive bladder cancer (NMIBC), which has a high recurrence and progression rate. Current diagnosis and surveillance methods present challenges, including risks to the patients. For this reason, urinary biomarkers have been proposed as alternatives to the methods. The goal of this mini-review is to describe urinary mRNA-based biomarkers available in current literature for NMIBC tumors, using the PubMed database. The search included the following keywords: “biomarkers” AND “bladder cancer” AND “urine” and “RNA” and “non-muscle”. The search yielded 11 original researchers utilizing mRNA-based urinary biomarkers. Although there is a wide variety of biomarkers described, the cohorts of the studies were not exclusively NMIBC, which is the subtype of BC that would mostly benefit from the introduction of a good follow-up biomarker, highlighting the need for randomized interventional trials for NMIBC. | en_US |
| Affilliation | University of Sao Paulo. Ribeirao Preto Medical School. Surgery and Anatomy Department. Uro-Oncology Laboratory. Ribeirão Preto, SP, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratory for Applied Science and Technology in Health. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratory for Applied Science and Technology in Health. Curitiba, PR, Brasil. | en_US |
| Affilliation | Politecnico di Torino. Department of Applied Science and Technology. Torino, Italy. | en_US |
| Affilliation | University of Sao Paulo. Ribeirao Preto Medical School. Surgery and Anatomy Department. Uro-Oncology Laboratory. Ribeirão Preto, SP, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratory for Applied Science and Technology in Health. Curitiba, PR, Brasil. | en_US |
| Affilliation | University of Sao Paulo. Ribeirao Preto Medical School. Surgery and Anatomy Department. Uro-Oncology Laboratory. Ribeirão Preto, SP, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratory for Applied Science and Technology in Health. Curitiba, PR, Brasil. | en_US |
| Subject | Non-muscle invasive bladder cancer | en_US |
| Subject | Urinary biomarkers | en_US |
| Subject | Muscle-invasive bladder cancer | en_US |
| Subject | Surveillance | en_US |
| Subject | Aggressiveness | en_US |
| Subject | mRNA-based | en_US |
| DeCS | Neoplasias não Músculo Invasivas da Bexiga | en_US |
| DeCS | Biomarcadores Tumorais | en_US |
