Author | Araújo, Flávio Marcos Gomes | |
Author | Sonoda, Ivan Vieira | |
Author | Rodrigues, Nilton Barnabé | |
Author | Teixeira, Rosângela | |
Author | Redondo, Rodrigo A. F. | |
Author | Oliveira, Guilherme Corrêa de | |
Access date | 2013-07-03T18:27:33Z | |
Available date | 2013-07-03T18:27:33Z | |
Document date | 2008 | |
Citation | ARAÚJO, Flávio Marcos Gomes et al. Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection. Mem Inst Oswaldo Cruz. 2008;103(6):611-4. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/6643 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Genetic variability in the 5' UTR and NS5A regions of hepatitis C virus RNA isolated from non-responding and responding patients with chronic HCV genotype 1 infection | pt_BR |
Type | Article | pt_BR |
DOI | S0074-02762008000600018 | |
Abstract | Sequence variation among different hepatitis C virus (HCV) isolates has adaptive significance and reflects the modes and intensities of selection mechanisms operating on the virus. In this work, we sought to investigate using classical population genetics parameters, the genetic variability of HCV genotype 1 using the 5' UTR and NS5A regions from treatment non-responding and responding groups of patients. Both regions showed low genetic varia-bility and the 5' UTR showed neutral deviation. No differences were observed in the nonsynonymous/synonymous nucleotide substitution ratio among groups for NS5A. The analysis of molecular variance test of the 5' UTR region showed an 11.94% variation among groups. Phylogenetic analysis showed no correlation between sequence variations and therapeutic responses | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Hospital das Clínicas. Instituto Alfa de Gastroenterologia | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biológicas. Laboratório de Biodiversidade e Evolução Molecular Departamento de Biologia Geral. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Santa Casa de Belo Horizonte. Programa de Pós-Graduação e Pesquisa. Belo Horizonte, MG, Brasil | pt_BR |
Subject | hepatitis C | pt_BR |
Subject | virus 5' | pt_BR |
Subject | UTR | pt_BR |
Subject | NS5A | pt_BR |
Subject | therapeutic | pt_BR |