| Author | Martins, Yuri Chaves | |
| Author | Gonçalves, Pamela Rosa | |
| Author | Ribeiro, Cláudio Tadeu Daniel | |
| Access date | 2024-10-17T14:40:44Z | |
| Available date | 2024-10-17T14:40:44Z | |
| Document date | 2024 | |
| Citation | MARTINS, Yuri Chaves; GONÇALVES, Pamela Rosa; RIBEIRO, Cláudio Tadeu Daniel. Theories of immune recognition: is anybody right? Immunology, v. 173, n. 2, p. 274-285, 21 July 2024. | |
| ISSN | 0019-2805 | |
| URI | https://www.arca.fiocruz.br/handle/icict/66570 | |
| Description | Produção científica do Laboratório de Pesquisa em Malária. | pt_BR |
| Sponsorship | Saint Louis University Department of Anesthesiology; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil), Grant/Award Number: 310445/2017-5; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (Faperj), Grant/Award Numbers: E-26/202.921/2018, E26/203.039/2023, 26010.002418/2019, 260003/001169/2020; Instituto Nacional de Ciência e Tecnologia (INCT) in Neuroimmunomodulation, Grant/Award Number: 465489/2014-1. | |
| Language | eng | en_US |
| Publisher | Wiley | |
| Rights | open access | |
| Title | Theories of immune recognition: is anybody right? | en_US |
| Type | Article | |
| DOI | 10.1111/imm.13839 | |
| Abstract | The clonal selection theory (CST) is the centrepiece of the current paradigm used to explain immune recognition and memory. Throughout the past decades, the original CST had been expanded and modified to explain new experimental evidences since its original publication by Burnet. This gave origin to new paradigms that govern experimental immunology nowadays, such as the associative recognition of antigen model and the stranger/danger signal model. However, these new theories also do not fully explain experimental findings such as natural autoimmune immunoglobulins, idiotypic networks, low and high dose tolerance, and dual-receptor T and B cells. To make sense of these empirical data, some authors have been trying to change the paradigm of immune cognition using a systemic approach, analogies with brain processing and concepts from second-order cybernetics. In the present paper, we review the CST and some of the theories/hypotheses derived from it, focusing on immune recognition. We point out their main weaknesses and highlight arguments made by their opponents and believers. We conclude that, until now, none of the proposed theories can fully explain the totality of immune phenomena and that a theory of everything is needed in immunology. | en_US |
| Affilliation | Saint Louis University School of Medicine. Department of Anesthesiology. Saint Louis, MO, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil. | |
| Subject | Immune cognition | en_US |
| Subject | Immunology | en_US |
| Subject | Neuroimmunology | en_US |
| Subject | Neuroscience | en_US |
| Subject | Tolerance | en_US |
| e-ISSN | 1365-2567 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 04 Educação de qualidade | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
