| Author | Araujo, Fabielle Marques dos Santos de | |
| Author | Faria, Robson Xavier | |
| Author | Amendoeira, Maria Regina Reis | |
| Access date | 2024-10-22T18:36:41Z | |
| Available date | 2024-10-22T18:36:41Z | |
| Document date | 2024 | |
| Citation | ARAUJO, Fabielle Marques dos Santos de; FARIA, Robson Xavier; AMENDOEIRA, Maria Regina Reis. The search for drugs derived from natural products for Toxoplasma gondii infection treatment in the last 20 years: a systematic review. Current Topics in Medicinal Chemistry, v. 24, n. 22, p. 1960-1999, 28 June 2024. | |
| ISSN | 1568-0266 | |
| URI | https://www.arca.fiocruz.br/handle/icict/66676 | |
| Description | Produção científica do Laboratório de Avaliação e Promoção da Saúde Ambiental. | pt_BR |
| Description | Produção científica do Laboratório de Protozoologia. | pt_BR |
| Sponsorship | This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) - Finance Code 001. Additionally, the student receives financing from the CNPq doctorate. | |
| Language | eng | en_US |
| Publisher | Bentham Science Publishers | |
| Rights | restricted access | |
| Title | The search for drugs derived from natural products for Toxoplasma gondii infection treatment in the last 20 years: a systematic review | en_US |
| Type | Article | |
| DOI | 10.2174/0115680266299409240606062235 | |
| Abstract | Introduction: Toxoplasmosis is a worldwide distributed zoonosis caused by Toxoplasma gondii (T. gondii), an obligate intracellular protozoan. The infection in immunocompetent hosts usually progresses with mild or no symptoms. However, in immunocompromised individuals, this disease can cause severe or fatal symptoms. Method: Sulfadiazine and pyrimethamine are two drugs used as standard therapies for human toxoplasmosis. Although they do not cause chronic infection, they may cause hematological toxicity, hypersensitivity, intolerance, teratogenic effects, gastrointestinal disorders, and bone marrow suppression. Results: The limited effect, significant toxicity, and emerging resistance to current drugs available to treat T. gondii infections require investigating other effective, nontoxic, and well-tolerated alternatives. Medicinal plants are, traditionally, the most promising sources used to treat infectious diseases. Conclusion: This review provides data on new therapeutic and prophylactic methods for T. gondii infection based on the use of extracts and/or compounds derived from natural products, which have been reported to be useful as alternative treatment options in the last 20 years. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Protozoologia. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Avaliação e Promoção da Saúde Ambiental. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Protozoologia. Rio de Janeiro, RJ, Brasil. | |
| Subject | Toxoplasmosis | en_US |
| Subject | Plant extract | en_US |
| Subject | Toxicity | en_US |
| Subject | Phytotherapy | en_US |
| Subject | Toxoplasma gondii | en_US |
| Subject | Immunocompetent | en_US |
| e-ISSN | 1873-4294 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
| xmlui.metadata.dc.subject.ods | 12 Consumo e produção responsáveis | |
